TY - JOUR
T1 - Self-organized neuronal subpopulations and network morphology underlying superbursts
AU - Kim, Byoungsoo
AU - Lee, Kyoung J.
N1 - Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) Grant funded by the Korea Government (MEST) (No. 2019R1A2C2005989). We thank Hyun Kim and Inhe Chung for critical reading of the manuscript.
Publisher Copyright:
© 2022 The Author(s). Published by IOP Publishing Ltd on behalf of the Institute of Physics and Deutsche Physikalische Gesellschaft.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Neural bursts are an important phenomenon that needs to be understood for their relevance to many different neurological diseases as well as neural computations. While there are different types of neuronal bursts, in this study we investigate the nature of population (as opposed to intrinsic cell-level) bursts, in particular, superbursts (SBs) that are a small (∼100 ms) packet of several population bursts (PBs). It has been suggested that neuronal PBs occur when there exists a delicate balance of system-wide excitation and inhibition and when recurrent excitation loops exist in the network. However, there has been no rigorous investigation on the relation between network morphology and (super)burst dynamics. Here we investigate the important issue based on a well-established Izhikevich network model of integrate-fire neurons. We have employed the overall conduction delay as our control parameter for tuning network morphology as well as its matching burst dynamics. Interestingly, we found that initially identical neurons self-organize to develop several distinct neuronal subpopulations, which are characterized by different spike firing patterns as well as local network properties. Moreover, a few different motifs of SB emerge according to a distinct mixture of neuronal subpopulations that, on average, fire at slightly different phases. Our analyses suggest that recurring motifs of different SBs reflect complex yet organized modular structures of different subpopulations.
AB - Neural bursts are an important phenomenon that needs to be understood for their relevance to many different neurological diseases as well as neural computations. While there are different types of neuronal bursts, in this study we investigate the nature of population (as opposed to intrinsic cell-level) bursts, in particular, superbursts (SBs) that are a small (∼100 ms) packet of several population bursts (PBs). It has been suggested that neuronal PBs occur when there exists a delicate balance of system-wide excitation and inhibition and when recurrent excitation loops exist in the network. However, there has been no rigorous investigation on the relation between network morphology and (super)burst dynamics. Here we investigate the important issue based on a well-established Izhikevich network model of integrate-fire neurons. We have employed the overall conduction delay as our control parameter for tuning network morphology as well as its matching burst dynamics. Interestingly, we found that initially identical neurons self-organize to develop several distinct neuronal subpopulations, which are characterized by different spike firing patterns as well as local network properties. Moreover, a few different motifs of SB emerge according to a distinct mixture of neuronal subpopulations that, on average, fire at slightly different phases. Our analyses suggest that recurring motifs of different SBs reflect complex yet organized modular structures of different subpopulations.
KW - complex network structure
KW - neural (super)burst
KW - neurodynamics
KW - population dynamics
UR - http://www.scopus.com/inward/record.url?scp=85129952006&partnerID=8YFLogxK
U2 - 10.1088/1367-2630/ac52c2
DO - 10.1088/1367-2630/ac52c2
M3 - Article
AN - SCOPUS:85129952006
SN - 1367-2630
VL - 24
JO - New Journal of Physics
JF - New Journal of Physics
IS - 4
M1 - 043047
ER -