Self-reported sleep impairment in functional dyspepsia and irritable bowel syndrome

Seung Young Kim, Rok Seon Choung, Seung Ku Lee, Jung Wan Choe, Sung Woo Jung, Jong Jin Hyun, Ja Seol Koo, Sang Woo Lee, Chol Shin

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Background/Aims Sleep impairment is a common complaint among patients with irritable bowel syndrome (IBS) and functional dyspepsia (FD). This study aimed to evaluate the prevalence of sleep impairment in FD or IBS patients, and to determine whether IBS-FD overlap induced more sleep disturbance than FD or IBS alone. Methods A population-based cohort in South Korea including 2251 subjects was asked about gastrointestinal symptoms including IBS and dyspepsia-related symptoms. In addition, sleep disturbance was measured using the Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale questionnaires. One-way ANOVA and logistic regression were used to assess differences among the 4 groups (healthy subjects, IBS alone, FD alone, and IBS-FD overlap). Results Of 2251 subjects who were surveyed by questionnaire, 2031 responded (92.5% response rate) and were analyzed. The prevalence of IBS, FD, and IBS-FD overlap was 8.0% (95% confidence interval [CI], 6.8-9.2%), 4.8% (95% CI, 3.9-5.8%), and 1.8% (95% CI, 1.2-2.4%), respectively. FD alone, but not IBS alone, was significantly associated with a poorer sleep quality index (OR, 2.68; 95% CI, 1.43-5.01) and more daytime sleepiness (OR, 2.21; 95% CI, 1.14-4.30), compared to healthy subjects. IBS-FD overlap had the greatest likelihood of a poorer sleep quality index (OR, 3.88; 95% CI, 1.83-8.19), daytime sleepiness (OR, 2.47; 95% CI, 1.01-5.67), and insomnia (OR, 2.84; 95% CI, 1.39-5.82), compared to healthy subjects. Conclusion A correlation between functional gastrointestinal disorders and sleep disturbance was demonstrated, which was significantly pronounced in the context of IBS-FD overlap.

Original languageEnglish
Pages (from-to)280-288
Number of pages9
JournalJournal of Neurogastroenterology and Motility
Issue number2
Publication statusPublished - 2018

Bibliographical note

Funding Information:
Financial support: This research was supported by the Korea Centers for Disease Control and Prevention (2012-E71005-00, 2013-E71005-00) and by the Bio and Medical Technology Development Program of the NRF funded by the Korean government, MSIP (NRF-2015M3A9B6027142). This study was partly supported by a Korea University Grant.

Publisher Copyright:
© 2018 The Korean Society of Neurogastroenterology and Motility.


  • Functional gastrointestinal disorder
  • Irritable bowel syndrome
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Gastroenterology


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