@article{b40d43d3e1b34a1582f8daa3d77dd036,
title = "Semen cuscutae administration improves hepatic lipid metabolism and adiposity in high fat diet-induced obese mice",
abstract = "Since arginase has been shown to compete with nitric oxide (NO) synthase, emerging evidence has reported that arginase inhibition improves obesity by increasing NO production. Semen cuscutae (SC), which is a well-known Chinese medicine, has multiple biological functions such as anti-oxidant function and immune regulation. In this study, we investigated whether the SC as a natural arginase inhibitor influences hepatic lipid abnormalities and whole-body adiposity in high-fat diet (HFD)-induced obese mice. The lipid accumulation was significantly reduced by SC treatment in oleic acid-induced hepatic steatosis in vitro. Additionally, SC supplementation substantially lowered HFD-induced increases in arginase activity and weights of liver and visceral fat tissue, while increasing hepatic NO. Furthermore, elevated mRNA expressions of sterol regulatory element-binding transcription factor 1 (SREBP-1c), fatty-acid synthase (FAS), peroxisome proliferator-activated receptor-gamma (PPAR-γ)1, and PPAR-γ2 in HFD-fed mice were significantly attenuated by SC supplementation. Taken together, SC, as a novel natural arginase inhibitor, showed anti-obesity properties by modulating hepatic arginase and NO production and metabolic pathways related to hepatic triglyceride (TG) metabolism.",
keywords = "Arginase inhibitor, Hepatic steatosis, Nitric oxide (NO), Obesity, Peroxisome proliferator-activated receptor (PPAR), Semen cuscutae (SC)",
author = "Jiyoung Moon and Ha, {Min Jin} and Shin, {Min Jeong} and Kim, {Oh Yoen} and Yoo, {Eun Hye} and Juhyun Song and Chung, {Ji Hyung}",
note = "Funding Information: Department of Public Health Sciences, BK21PLUS Program in Embodiment: Health-Society Interaction, Graduate School, Korea University, Seoul 02841, Korea; answldud8503@naver.com (J.M.); 90minjin@hanmail.net (M.J.H.); mjshin@korea.ac.kr (M.-J.S.); dmsp1539@naver.com (E.H.Y.) Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT 84112, USA Department of Food Science and Nutrition, Dong-A University, Busan 49315, Korea; oykim@dau.ac.kr Department of Anatomy, Chonnam National University Medical School, Gwangju 61469, Korea Department of Biotechnology, College of Life Science, CHA University, Gyeonggi-do 11160, Korea Correspondence: alj1008@nate.com (J.S.); jhchung@cha.ac.kr (J.H.C.) These authors equally contributed to this work. Funding Information: This article was based on a dissertation project titled “Effects of Semen cuscutae supplementation on hepatic metabolism and whole body adiposity in high-fat diet induced obese mice,” which was supported by funded by grants 2016R1D1A1B03930394 and 2019R1F1A1054111 from the Basic Science Research Program and Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (NRF-2012M3A9C4048761). Funding Information: Funding: This article was based on a dissertation project titled “Effects of Semen cuscutae supplementation on hepatic metabolism and whole body adiposity in high-fat diet induced obese mice,” which was supported by funded by grants 2016R1D1A1B03930394 and 2019R1F1A1054111 from the Basic Science Research Program and Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science & ICT (NRF-2012M3A9C4048761). Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2019",
month = dec,
doi = "10.3390/nu11123035",
language = "English",
volume = "11",
journal = "Nutrients",
issn = "2072-6643",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "12",
}