Semi-continuous immobilized cultivation of Porphyridium cruentum for sulfated polysaccharides production

Sang Il Han, Min Seo Jeon, Yun Hwan Park, Sok Kim, Yoon E. Choi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


In this study, semi-continuous immobilized cultivation of Porphyridium cruentum through calcium alginate beads was performed for sulfated polysaccharides (SPs) production. The cell biomass and daily SPs productivity in the calcium alginate bead immobilized culture were increased by up to 79 ± 3.4% and 45.6 ± 3.2%, compared to those in the control, respectively. Furthermore, simultaneous application of immobilization and blue wavelength illumination further increased the phycobiliproteins content by 260 ± 9%, compared to those in the control. Similarly, nutrient deficiencies in combination with immobilization increased daily SPs productivity by about twice that of the control. The chemical composition and biological activity of the extracellular polymeric substances produced through immobilization were similar to those of the control. This study suggests the potential application of calcium alginate beads-based immobilization for continuous and high-efficiency SPs production using P. cruentum.

Original languageEnglish
Article number125816
JournalBioresource technology
Publication statusPublished - 2021 Dec


  • Calcium alginate bead
  • Immobilized culture
  • Porphyridium cruentum
  • Semi-continuous culture
  • Sulfated polysaccharides

ASJC Scopus subject areas

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal


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