Sensing of cancer DNA using quartz crystal microbalance

Chanho Park; Hyunjun Park; Sungsoo Na

Sensing of cancer DNA using quartz crystal microbalance

Chanho Park, Hyunjun Park, Sungsoo Na

Research output: Contribution to conference › Paper › peer-review

Abstract

A label-free and high-sensitive sensing method of cancer DNA mutations using QCM(quartz crystal microbalance) is developed. The detection is based on the evaluation of the resonance frequecny. When probe DNA (pDNA) is introduced on quartz of sensor of QCM, the resonance frequency is shifted. When pDNA captures target mutant DNA through DNA hybridization, an additional resonance frequency shift occurs due to mass change in association with target DNA. The platform is able to sense EGFR, lung cancer mutant DNA with a limit of detection (LOD) of 1.0 nM.

Original language	English
Publication status	Published - 2017
Event	24th International Congress on Sound and Vibration, ICSV 2017 - London, United Kingdom Duration: 2017 Jul 23 → 2017 Jul 27

Other

Other	24th International Congress on Sound and Vibration, ICSV 2017
Country/Territory	United Kingdom
City	London
Period	17/7/23 → 17/7/27

Keywords

Epidermal growth factor receptor (EGFR)
In situ detection
Mutation
Nano-porous
Quartz crystal microbalance (QCM)

ASJC Scopus subject areas

Acoustics and Ultrasonics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "Sensing of cancer DNA using quartz crystal microbalance",

abstract = "A label-free and high-sensitive sensing method of cancer DNA mutations using QCM(quartz crystal microbalance) is developed. The detection is based on the evaluation of the resonance frequecny. When probe DNA (pDNA) is introduced on quartz of sensor of QCM, the resonance frequency is shifted. When pDNA captures target mutant DNA through DNA hybridization, an additional resonance frequency shift occurs due to mass change in association with target DNA. The platform is able to sense EGFR, lung cancer mutant DNA with a limit of detection (LOD) of 1.0 nM.",

keywords = "Epidermal growth factor receptor (EGFR), In situ detection, Mutation, Nano-porous, Quartz crystal microbalance (QCM)",

author = "Chanho Park and Hyunjun Park and Sungsoo Na",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) under Grant Number NRF-2007-0056094 and NRF-2014R1A2A1A11052389 which are funded by the Ministry of Science, ICT & Future Planning.; 24th International Congress on Sound and Vibration, ICSV 2017 ; Conference date: 23-07-2017 Through 27-07-2017",

year = "2017",

language = "English",

}

TY - CONF

T1 - Sensing of cancer DNA using quartz crystal microbalance

AU - Park, Chanho

AU - Park, Hyunjun

AU - Na, Sungsoo

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) under Grant Number NRF-2007-0056094 and NRF-2014R1A2A1A11052389 which are funded by the Ministry of Science, ICT & Future Planning.

PY - 2017

Y1 - 2017

N2 - A label-free and high-sensitive sensing method of cancer DNA mutations using QCM(quartz crystal microbalance) is developed. The detection is based on the evaluation of the resonance frequecny. When probe DNA (pDNA) is introduced on quartz of sensor of QCM, the resonance frequency is shifted. When pDNA captures target mutant DNA through DNA hybridization, an additional resonance frequency shift occurs due to mass change in association with target DNA. The platform is able to sense EGFR, lung cancer mutant DNA with a limit of detection (LOD) of 1.0 nM.

AB - A label-free and high-sensitive sensing method of cancer DNA mutations using QCM(quartz crystal microbalance) is developed. The detection is based on the evaluation of the resonance frequecny. When probe DNA (pDNA) is introduced on quartz of sensor of QCM, the resonance frequency is shifted. When pDNA captures target mutant DNA through DNA hybridization, an additional resonance frequency shift occurs due to mass change in association with target DNA. The platform is able to sense EGFR, lung cancer mutant DNA with a limit of detection (LOD) of 1.0 nM.

KW - Epidermal growth factor receptor (EGFR)

KW - In situ detection

KW - Mutation

KW - Nano-porous

KW - Quartz crystal microbalance (QCM)

UR - http://www.scopus.com/inward/record.url?scp=85029439724&partnerID=8YFLogxK

M3 - Paper

AN - SCOPUS:85029439724

T2 - 24th International Congress on Sound and Vibration, ICSV 2017

Y2 - 23 July 2017 through 27 July 2017

ER -

Sensing of cancer DNA using quartz crystal microbalance

Abstract

Other

Keywords

ASJC Scopus subject areas

UN SDGs

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