Sensitive optical bio-sensing of p-type WSe2 hybridized with fluorescent dye attached DNA by doping and de-doping effects

Kyu Hyun Han, Jun Young Kim, Seong Gi Jo, Changwon Seo, Jeongyong Kim, Jinsoo Joo

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


Layered transition metal dichalcogenides, such as MoS2, WSe2 and WS2, are exciting two-dimensional (2D) materials because they possess tunable optical and electrical properties that depend on the number of layers. In this study, the nanoscale photoluminescence (PL) characteristics of the p-type WSe2 monolayer, and WSe2 layers hybridized with the fluorescent dye Cy3 attached to probe-DNA (Cy3/p-DNA), have been investigated as a function of the concentration of Cy3/DNA by using high-resolution laser confocal microscopy. With increasing concentration of Cy3/p-DNA, the measured PL intensity decreases and its peak is red-shifted, suggesting that the WSe2 layer has been p-type doped with Cy3/p-DNA. Then, the PL intensity of the WSe2/Cy3/p-DNA hybrid system increases and the peak is blue-shifted through hybridization with relatively small amounts of target-DNA (t-DNA) (50-100 nM). This effect originates from charge and energy transfer from the Cy3/DNA to the WSe2. For t-DNA detection, our systems using p-type WSe2 have the merit in terms of the increase of PL intensity. The p-type WSe2 monolayers can be a promising nanoscale 2D material for sensitive optical bio-sensing based on the doping and de-doping responses to biomaterials.

Original languageEnglish
Article number435501
Issue number43
Publication statusPublished - 2017 Sept 26

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant founded by the Korea government (MSIP) (No. 2015R1A2A2A01003805) and by the Center for Advanced Meta Materials (CAMM) founded by the MSIP as the Global Frontier Project (No. 2014M3A6B3063710).

Publisher Copyright:
© 2017 IOP Publishing Ltd.


  • WSe
  • bio-sensing
  • doping
  • photoluminescence
  • transition metal dichalcogenide

ASJC Scopus subject areas

  • Bioengineering
  • General Chemistry
  • General Materials Science
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering


Dive into the research topics of 'Sensitive optical bio-sensing of p-type WSe2 hybridized with fluorescent dye attached DNA by doping and de-doping effects'. Together they form a unique fingerprint.

Cite this