An anionic species of 2,5-norbornadiene was generated and brominated using a flow reactor. In the second step, 2-bromo-2,5-norbornadiene was lithiated with LTMP and reacted with tributyltin chloride. Finally, an integrated one-flow synthesis using various electrophiles was achieved within 3 min to prepare 2-bromo-2,5-norbornadienes bearing a functional group at the 3-position.
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© 2018 The Royal Society of Chemistry.
ASJC Scopus subject areas
- Chemistry (miscellaneous)
- Chemical Engineering (miscellaneous)
- Process Chemistry and Technology
- Fluid Flow and Transfer Processes