Sequential double C-H functionalization of 2,5-norbornadiene in flow

Heejin Kim, Zuoyufan Yin, Hidehiro Sakurai, Jun Ichi Yoshida

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


An anionic species of 2,5-norbornadiene was generated and brominated using a flow reactor. In the second step, 2-bromo-2,5-norbornadiene was lithiated with LTMP and reacted with tributyltin chloride. Finally, an integrated one-flow synthesis using various electrophiles was achieved within 3 min to prepare 2-bromo-2,5-norbornadienes bearing a functional group at the 3-position.

Original languageEnglish
Pages (from-to)635-639
Number of pages5
JournalReaction Chemistry and Engineering
Issue number5
Publication statusPublished - 2018 Oct
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2018 The Royal Society of Chemistry.

ASJC Scopus subject areas

  • Catalysis
  • Chemistry (miscellaneous)
  • Chemical Engineering (miscellaneous)
  • Process Chemistry and Technology
  • Fluid Flow and Transfer Processes


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