In this chapter, a post-polymerization double-modification strategy involving sequential thiol-epoxy and esterification reactions is discussed for the preparation of bifunctionalized homopolymer sequences. For this, initially, the synthesis and stability of poly(glycidyl methacrylate), the primary reactive scaffold, are considered. Double modification of the glycidyl units through consecutive thiol-epoxy and esterification reactions is then examined along with its potential to give rise to functionalized molecular bottlebrushes. Finally, application of this strategy for the preparation of amphipathic homopolymer sequences and their application in the arena of siRNA delivery are discussed.
Bibliographical noteFunding Information:
M.C.S. gratefully acknowledges Nanyang Technological University (Singapore) for financial support. A.K. thanks A. D. Schlüter (ETH-Z) for support.
© Springer International Publishing Switzerland
- Amphipathic polymers
- Bifunctionalized homopolymers
- Dual-functional polymers Poly(glycidyl methacrylate) Post-polymerization modification Sequential reactions siRNA delivery Thiol-epoxy reaction
ASJC Scopus subject areas
- Chemical Engineering(all)
- Organic Chemistry
- Polymers and Plastics