Serotonergic genes and personality traits in the Korean population

Byung Joo Ham, Yong Ho Kim, Myung Jin Choi, Ji Hyun Cha, Yun Kyeung Choi, Min Soo Lee

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


Serotonergic genes have been implicated in mood disorders, alcoholism and certain personality traits. The goal of this study was to investigate the relationship between personality traits and several important genes in the serotonin system. The participants included 146 healthy adults with no history of psychiatric disorders or other physical illness during the last 6 months. All participants were tested by the Temperament and Character Inventory (TCI) and genotyped serotonin transporter, serotonin receptors (5-HT2A and 5-HT6) and tryptophan hydroxylase gene polymorphisms. Genotyping was analyzed with polymerase chain reaction. Differences in TCI dimensions and sub-scales among three groups were examined with ANOVA. Our result suggested that 5-HT2A receptor gene polymorphism (A-1438G) appears to be associated with self-determinism and self-transcendence (ST). Our result also indicated a significant relationship between 5-HT6 receptor gene polymorphism (C267T) and ST. Further studies of polymorphisms of other genes and their interactions may clarify the complex relationship between personality and genes.

Original languageEnglish
Pages (from-to)2-5
Number of pages4
JournalNeuroscience Letters
Issue number1
Publication statusPublished - 2004 Jan 2
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by a grant of the Korean Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (KPGRN-R-Ø4).


  • Genetics
  • Personality traits
  • Polymorphism
  • Serotonin transporter
  • Serotonin-2A receptor
  • Serotonin-6 receptor
  • Tryptophan hydroxylase

ASJC Scopus subject areas

  • General Neuroscience


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