Serotonergic genes and personality traits in the Korean population

Byung Joo Ham; Yong Ho Kim; Myung Jin Choi; Ji Hyun Cha; Yun Kyeung Choi; Min Soo Lee

doi:10.1016/S0304-3940(03)00753-5

Serotonergic genes and personality traits in the Korean population

Byung Joo Ham, Yong Ho Kim, Myung Jin Choi, Ji Hyun Cha, Yun Kyeung Choi, Min Soo Lee

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

Serotonergic genes have been implicated in mood disorders, alcoholism and certain personality traits. The goal of this study was to investigate the relationship between personality traits and several important genes in the serotonin system. The participants included 146 healthy adults with no history of psychiatric disorders or other physical illness during the last 6 months. All participants were tested by the Temperament and Character Inventory (TCI) and genotyped serotonin transporter, serotonin receptors (5-HT_2A and 5-HT₆) and tryptophan hydroxylase gene polymorphisms. Genotyping was analyzed with polymerase chain reaction. Differences in TCI dimensions and sub-scales among three groups were examined with ANOVA. Our result suggested that 5-HT_2A receptor gene polymorphism (A-1438G) appears to be associated with self-determinism and self-transcendence (ST). Our result also indicated a significant relationship between 5-HT₆ receptor gene polymorphism (C267T) and ST. Further studies of polymorphisms of other genes and their interactions may clarify the complex relationship between personality and genes.

Original language	English
Pages (from-to)	2-5
Number of pages	4
Journal	Neuroscience Letters
Volume	354
Issue number	1
DOIs	https://doi.org/10.1016/S0304-3940(03)00753-5
Publication status	Published - 2004 Jan 2
Externally published	Yes

Keywords

Genetics
Personality traits
Polymorphism
Serotonin transporter
Serotonin-2A receptor
Serotonin-6 receptor
Tryptophan hydroxylase

ASJC Scopus subject areas

Neuroscience(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0304-3940(03)00753-5

Cite this

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title = "Serotonergic genes and personality traits in the Korean population",

abstract = "Serotonergic genes have been implicated in mood disorders, alcoholism and certain personality traits. The goal of this study was to investigate the relationship between personality traits and several important genes in the serotonin system. The participants included 146 healthy adults with no history of psychiatric disorders or other physical illness during the last 6 months. All participants were tested by the Temperament and Character Inventory (TCI) and genotyped serotonin transporter, serotonin receptors (5-HT2A and 5-HT6) and tryptophan hydroxylase gene polymorphisms. Genotyping was analyzed with polymerase chain reaction. Differences in TCI dimensions and sub-scales among three groups were examined with ANOVA. Our result suggested that 5-HT2A receptor gene polymorphism (A-1438G) appears to be associated with self-determinism and self-transcendence (ST). Our result also indicated a significant relationship between 5-HT6 receptor gene polymorphism (C267T) and ST. Further studies of polymorphisms of other genes and their interactions may clarify the complex relationship between personality and genes.",

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author = "Ham, {Byung Joo} and Kim, {Yong Ho} and Choi, {Myung Jin} and Cha, {Ji Hyun} and Choi, {Yun Kyeung} and Lee, {Min Soo}",

note = "Funding Information: This study was supported by a grant of the Korean Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (KPGRN-R-{\O}4).",

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doi = "10.1016/S0304-3940(03)00753-5",

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AU - Kim, Yong Ho

AU - Choi, Myung Jin

AU - Cha, Ji Hyun

AU - Choi, Yun Kyeung

AU - Lee, Min Soo

N1 - Funding Information: This study was supported by a grant of the Korean Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (KPGRN-R-Ø4).

PY - 2004/1/2

Y1 - 2004/1/2

N2 - Serotonergic genes have been implicated in mood disorders, alcoholism and certain personality traits. The goal of this study was to investigate the relationship between personality traits and several important genes in the serotonin system. The participants included 146 healthy adults with no history of psychiatric disorders or other physical illness during the last 6 months. All participants were tested by the Temperament and Character Inventory (TCI) and genotyped serotonin transporter, serotonin receptors (5-HT2A and 5-HT6) and tryptophan hydroxylase gene polymorphisms. Genotyping was analyzed with polymerase chain reaction. Differences in TCI dimensions and sub-scales among three groups were examined with ANOVA. Our result suggested that 5-HT2A receptor gene polymorphism (A-1438G) appears to be associated with self-determinism and self-transcendence (ST). Our result also indicated a significant relationship between 5-HT6 receptor gene polymorphism (C267T) and ST. Further studies of polymorphisms of other genes and their interactions may clarify the complex relationship between personality and genes.

AB - Serotonergic genes have been implicated in mood disorders, alcoholism and certain personality traits. The goal of this study was to investigate the relationship between personality traits and several important genes in the serotonin system. The participants included 146 healthy adults with no history of psychiatric disorders or other physical illness during the last 6 months. All participants were tested by the Temperament and Character Inventory (TCI) and genotyped serotonin transporter, serotonin receptors (5-HT2A and 5-HT6) and tryptophan hydroxylase gene polymorphisms. Genotyping was analyzed with polymerase chain reaction. Differences in TCI dimensions and sub-scales among three groups were examined with ANOVA. Our result suggested that 5-HT2A receptor gene polymorphism (A-1438G) appears to be associated with self-determinism and self-transcendence (ST). Our result also indicated a significant relationship between 5-HT6 receptor gene polymorphism (C267T) and ST. Further studies of polymorphisms of other genes and their interactions may clarify the complex relationship between personality and genes.

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KW - Polymorphism

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KW - Serotonin-2A receptor

KW - Serotonin-6 receptor

KW - Tryptophan hydroxylase

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Serotonergic genes and personality traits in the Korean population

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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