Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolated from invasive infections after optional use of the 7-valent conjugate vaccine in Korea, 2006-2010

Eun Young Cho; Hyunju Lee; Eun Hwa Choi; Yae Jean Kim; Byung Wook Eun; Yong Kyun Cho; Yun Kyung Kim; Dae Sun Jo; Hye Soo Lee; Jina Lee; Mi Na Kim; Dong Soo Kim; Hoan Jong Lee

doi:10.1016/j.diagmicrobio.2013.12.016

Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolated from invasive infections after optional use of the 7-valent conjugate vaccine in Korea, 2006-2010

Eun Young Cho, Hyunju Lee, Eun Hwa Choi, Yae Jean Kim, Byung Wook Eun, Yong Kyun Cho, Yun Kyung Kim, Dae Sun Jo, Hye Soo Lee, Jina Lee, Mi Na Kim, Dong Soo Kim, Hoan Jong Lee

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Abstract

This study examined the serotype distribution and antimicrobial resistance of pneumococcal isolates from invasive infections in children between 2006 and 2010, when the 7-valent pneumococcal conjugate vaccine (PCV7) was offered as an optional vaccine in Korea. Among 140 isolates collected from 8 centers, the common serotypes were 19A (22.9%), 19 F (12.1%), and 6B (8.6%). Between 2006 and 2010, PCV7 serotypes decreased from 62.5% to 21.4% (P = 0.002), whereas three 13-valent pneumococcal conjugate vaccine (PCV13)-specific serotypes (3, 6A, and 19A) increased from 18.8% to 42.9% (P = 0.016). Among 102 multidrug-resistant isolates, the proportion of PCV7 serotypes decreased from 65.2% to 21.7% (P = 0.001), and 3 PCV13-specific serotypes increased from 17.4% to 47.8% (P = 0.008). Optional PCV7 vaccination has influenced the proportion of PCV7 serotypes in Korea, resulting in a decrease, whereas the proportions of 3 PCV13-specific serotypes, particularly 19A, have increased.

Original language	English
Pages (from-to)	481-486
Number of pages	6
Journal	Diagnostic Microbiology and Infectious Disease
Volume	78
Issue number	4
DOIs	https://doi.org/10.1016/j.diagmicrobio.2013.12.016
Publication status	Published - 2014 Apr
Externally published	Yes

Bibliographical note

Funding Information:
This study was supported in part by the Seoul National University Hospital grant (06-2012-1040), which was underwritten by Wyeth Research.

Funding Information:
Lee HJ received research grants from Boryung Biopharma, GlaxoSmithKline Korea Ltd., Green Cross Company, Novartis Korea Ltd., Pfizer Inc., and Sanofi Pasteur.

Keywords

Antimicrobial resistance
Pneumococcal vaccines
Serotype
Streptococcus pneumoniae

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.diagmicrobio.2013.12.016

Cite this

Cho, E. Y., Lee, H., Choi, E. H., Kim, Y. J., Eun, B. W., Cho, Y. K., Kim, Y. K., Jo, D. S., Lee, H. S., Lee, J., Kim, M. N., Kim, D. S., & Lee, H. J. (2014). Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolated from invasive infections after optional use of the 7-valent conjugate vaccine in Korea, 2006-2010. Diagnostic Microbiology and Infectious Disease, 78(4), 481-486. https://doi.org/10.1016/j.diagmicrobio.2013.12.016

Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolated from invasive infections after optional use of the 7-valent conjugate vaccine in Korea, 2006-2010. / Cho, Eun Young; Lee, Hyunju; Choi, Eun Hwa et al.
In: Diagnostic Microbiology and Infectious Disease, Vol. 78, No. 4, 04.2014, p. 481-486.

Research output: Contribution to journal › Article › peer-review

Cho, EY, Lee, H, Choi, EH, Kim, YJ, Eun, BW, Cho, YK, Kim, YK, Jo, DS, Lee, HS, Lee, J, Kim, MN, Kim, DS & Lee, HJ 2014, 'Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolated from invasive infections after optional use of the 7-valent conjugate vaccine in Korea, 2006-2010', Diagnostic Microbiology and Infectious Disease, vol. 78, no. 4, pp. 481-486. https://doi.org/10.1016/j.diagmicrobio.2013.12.016

@article{1f5160f36b7c4e14a6ae0a9637d9893c,

title = "Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolated from invasive infections after optional use of the 7-valent conjugate vaccine in Korea, 2006-2010",

abstract = "This study examined the serotype distribution and antimicrobial resistance of pneumococcal isolates from invasive infections in children between 2006 and 2010, when the 7-valent pneumococcal conjugate vaccine (PCV7) was offered as an optional vaccine in Korea. Among 140 isolates collected from 8 centers, the common serotypes were 19A (22.9%), 19 F (12.1%), and 6B (8.6%). Between 2006 and 2010, PCV7 serotypes decreased from 62.5% to 21.4% (P = 0.002), whereas three 13-valent pneumococcal conjugate vaccine (PCV13)-specific serotypes (3, 6A, and 19A) increased from 18.8% to 42.9% (P = 0.016). Among 102 multidrug-resistant isolates, the proportion of PCV7 serotypes decreased from 65.2% to 21.7% (P = 0.001), and 3 PCV13-specific serotypes increased from 17.4% to 47.8% (P = 0.008). Optional PCV7 vaccination has influenced the proportion of PCV7 serotypes in Korea, resulting in a decrease, whereas the proportions of 3 PCV13-specific serotypes, particularly 19A, have increased.",

keywords = "Antimicrobial resistance, Pneumococcal vaccines, Serotype, Streptococcus pneumoniae",

author = "Cho, {Eun Young} and Hyunju Lee and Choi, {Eun Hwa} and Kim, {Yae Jean} and Eun, {Byung Wook} and Cho, {Yong Kyun} and Kim, {Yun Kyung} and Jo, {Dae Sun} and Lee, {Hye Soo} and Jina Lee and Kim, {Mi Na} and Kim, {Dong Soo} and Lee, {Hoan Jong}",

note = "Funding Information: This study was supported in part by the Seoul National University Hospital grant (06-2012-1040), which was underwritten by Wyeth Research. Funding Information: Lee HJ received research grants from Boryung Biopharma, GlaxoSmithKline Korea Ltd., Green Cross Company, Novartis Korea Ltd., Pfizer Inc., and Sanofi Pasteur. ",

year = "2014",

month = apr,

doi = "10.1016/j.diagmicrobio.2013.12.016",

language = "English",

volume = "78",

pages = "481--486",

journal = "Diagnostic Microbiology and Infectious Disease",

issn = "0732-8893",

publisher = "Elsevier Inc.",

number = "4",

}

TY - JOUR

T1 - Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolated from invasive infections after optional use of the 7-valent conjugate vaccine in Korea, 2006-2010

AU - Cho, Eun Young

AU - Lee, Hyunju

AU - Choi, Eun Hwa

AU - Kim, Yae Jean

AU - Eun, Byung Wook

AU - Cho, Yong Kyun

AU - Kim, Yun Kyung

AU - Jo, Dae Sun

AU - Lee, Hye Soo

AU - Lee, Jina

AU - Kim, Mi Na

AU - Kim, Dong Soo

AU - Lee, Hoan Jong

N1 - Funding Information: This study was supported in part by the Seoul National University Hospital grant (06-2012-1040), which was underwritten by Wyeth Research. Funding Information: Lee HJ received research grants from Boryung Biopharma, GlaxoSmithKline Korea Ltd., Green Cross Company, Novartis Korea Ltd., Pfizer Inc., and Sanofi Pasteur.

PY - 2014/4

Y1 - 2014/4

N2 - This study examined the serotype distribution and antimicrobial resistance of pneumococcal isolates from invasive infections in children between 2006 and 2010, when the 7-valent pneumococcal conjugate vaccine (PCV7) was offered as an optional vaccine in Korea. Among 140 isolates collected from 8 centers, the common serotypes were 19A (22.9%), 19 F (12.1%), and 6B (8.6%). Between 2006 and 2010, PCV7 serotypes decreased from 62.5% to 21.4% (P = 0.002), whereas three 13-valent pneumococcal conjugate vaccine (PCV13)-specific serotypes (3, 6A, and 19A) increased from 18.8% to 42.9% (P = 0.016). Among 102 multidrug-resistant isolates, the proportion of PCV7 serotypes decreased from 65.2% to 21.7% (P = 0.001), and 3 PCV13-specific serotypes increased from 17.4% to 47.8% (P = 0.008). Optional PCV7 vaccination has influenced the proportion of PCV7 serotypes in Korea, resulting in a decrease, whereas the proportions of 3 PCV13-specific serotypes, particularly 19A, have increased.

AB - This study examined the serotype distribution and antimicrobial resistance of pneumococcal isolates from invasive infections in children between 2006 and 2010, when the 7-valent pneumococcal conjugate vaccine (PCV7) was offered as an optional vaccine in Korea. Among 140 isolates collected from 8 centers, the common serotypes were 19A (22.9%), 19 F (12.1%), and 6B (8.6%). Between 2006 and 2010, PCV7 serotypes decreased from 62.5% to 21.4% (P = 0.002), whereas three 13-valent pneumococcal conjugate vaccine (PCV13)-specific serotypes (3, 6A, and 19A) increased from 18.8% to 42.9% (P = 0.016). Among 102 multidrug-resistant isolates, the proportion of PCV7 serotypes decreased from 65.2% to 21.7% (P = 0.001), and 3 PCV13-specific serotypes increased from 17.4% to 47.8% (P = 0.008). Optional PCV7 vaccination has influenced the proportion of PCV7 serotypes in Korea, resulting in a decrease, whereas the proportions of 3 PCV13-specific serotypes, particularly 19A, have increased.

KW - Antimicrobial resistance

KW - Pneumococcal vaccines

KW - Serotype

KW - Streptococcus pneumoniae

UR - http://www.scopus.com/inward/record.url?scp=84895884212&partnerID=8YFLogxK

U2 - 10.1016/j.diagmicrobio.2013.12.016

DO - 10.1016/j.diagmicrobio.2013.12.016

M3 - Article

C2 - 24529940

AN - SCOPUS:84895884212

SN - 0732-8893

VL - 78

SP - 481

EP - 486

JO - Diagnostic Microbiology and Infectious Disease

JF - Diagnostic Microbiology and Infectious Disease

IS - 4

ER -

Serotype distribution and antibiotic resistance of Streptococcus pneumoniae isolated from invasive infections after optional use of the 7-valent conjugate vaccine in Korea, 2006-2010

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this