Serpinb11 expression is associated with prognosis of high-grade serous and clear cell carcinoma of the ovary

SOO JIN PARK; WHASUN LIM; JAEHEE MUN; HAERIN PAIK; SUNWOO PARK; HYUNJI LIM; JUNHWAN KIM; EUN JI LEE; GA WON YIM; NARA LEE; CHEOL LEE; JAE WEON KIM; GWONHWA SONG; HEE SEUNG KIM

doi:10.21873/INVIVO.12547

Serpinb11 expression is associated with prognosis of high-grade serous and clear cell carcinoma of the ovary

SOO JIN PARK, WHASUN LIM, JAEHEE MUN, HAERIN PAIK, SUNWOO PARK, HYUNJI LIM, JUNHWAN KIM, EUN JI LEE, GA WON YIM, NARA LEE, CHEOL LEE, JAE WEON KIM, GWONHWA SONG, HEE SEUNG KIM

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2 Citations (Scopus)

Abstract

Background/Aim: To evaluate the role of serine protease inhibitor B11 (SERPINB11) expression as a prognostic biomarker in high-grade serous carcinoma (HGSC) and clear cell carcinoma of the ovary (CCC). Materials and Methods: We obtained tumor tissues from patients with HGSC (n=145) and CCC (n=59). We evaluated immunohistochemically the expression of SERPINB11 and investigated whether SERPINB11 expression affects platinum-resistance and the prognosis of HGSC and CCC. Results: High expression of SERPINB11 was more common in CCC than in HGSC (57.6% vs. 28.3%; p<0.01), and SEPRINB11 expression did not correlate with platinum-resistance of HGSC and CCC. High expression of SERPINB11 was associated with worse progression-free survival and overall survival with marginal significance in HGSC; no relation between SERPINB11 expression and the prognosis of CCC was found. Conclusion: SERPINB11 expression maybe a prognostic biomarker for HGSC.

Original language	English
Pages (from-to)	2647-2653
Number of pages	7
Journal	In Vivo
Volume	35
Issue number	5
DOIs	https://doi.org/10.21873/INVIVO.12547
Publication status	Published - 2021 Oct

Bibliographical note

Funding Information:
This study was supported by grants from Seoul National University (No. 800-20180190; 800-20190437; 800-20200309; 800-20200458).

Publisher Copyright:
© 2021 International Institute of Anticancer Research. All rights reserved.

Keywords

Clear cell
High-grade serous
Ovarian cancer
Prognosis
SERPINB11

ASJC Scopus subject areas

General Biochemistry,Genetics and Molecular Biology
Cancer Research
Pharmacology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.21873/INVIVO.12547

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PARK, SOO. JIN., LIM, WHASUN., MUN, JAEHEE., PAIK, HAERIN., PARK, SUNWOO., LIM, HYUNJI., KIM, JUNHWAN., LEE, EUN. JI., YIM, GA. WON., LEE, NARA., LEE, CHEOL., KIM, JAE. WEON., SONG, GWONHWA., & KIM, HEE. SEUNG. (2021). Serpinb11 expression is associated with prognosis of high-grade serous and clear cell carcinoma of the ovary. In Vivo, 35(5), 2647-2653. https://doi.org/10.21873/INVIVO.12547

PARK, SOOJIN, LIM, WHASUN, MUN, JAEHEE, PAIK, HAERIN, PARK, SUNWOO, LIM, HYUNJI, KIM, JUNHWAN, LEE, EUNJI, YIM, GAWON, LEE, NARA, LEE, CHEOL, KIM, JAEWEON, SONG, GWONHWA & KIM, HEESEUNG 2021, 'Serpinb11 expression is associated with prognosis of high-grade serous and clear cell carcinoma of the ovary', In Vivo, vol. 35, no. 5, pp. 2647-2653. https://doi.org/10.21873/INVIVO.12547

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title = "Serpinb11 expression is associated with prognosis of high-grade serous and clear cell carcinoma of the ovary",

abstract = "Background/Aim: To evaluate the role of serine protease inhibitor B11 (SERPINB11) expression as a prognostic biomarker in high-grade serous carcinoma (HGSC) and clear cell carcinoma of the ovary (CCC). Materials and Methods: We obtained tumor tissues from patients with HGSC (n=145) and CCC (n=59). We evaluated immunohistochemically the expression of SERPINB11 and investigated whether SERPINB11 expression affects platinum-resistance and the prognosis of HGSC and CCC. Results: High expression of SERPINB11 was more common in CCC than in HGSC (57.6% vs. 28.3%; p<0.01), and SEPRINB11 expression did not correlate with platinum-resistance of HGSC and CCC. High expression of SERPINB11 was associated with worse progression-free survival and overall survival with marginal significance in HGSC; no relation between SERPINB11 expression and the prognosis of CCC was found. Conclusion: SERPINB11 expression maybe a prognostic biomarker for HGSC.",

keywords = "Clear cell, High-grade serous, Ovarian cancer, Prognosis, SERPINB11",

author = "PARK, {SOO JIN} and WHASUN LIM and JAEHEE MUN and HAERIN PAIK and SUNWOO PARK and HYUNJI LIM and JUNHWAN KIM and LEE, {EUN JI} and YIM, {GA WON} and NARA LEE and CHEOL LEE and KIM, {JAE WEON} and GWONHWA SONG and KIM, {HEE SEUNG}",

note = "Funding Information: This study was supported by grants from Seoul National University (No. 800-20180190; 800-20190437; 800-20200309; 800-20200458). Publisher Copyright: {\textcopyright} 2021 International Institute of Anticancer Research. All rights reserved.",

year = "2021",

month = oct,

doi = "10.21873/INVIVO.12547",

language = "English",

volume = "35",

pages = "2647--2653",

journal = "In Vivo",

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TY - JOUR

T1 - Serpinb11 expression is associated with prognosis of high-grade serous and clear cell carcinoma of the ovary

AU - PARK, SOO JIN

AU - LIM, WHASUN

AU - MUN, JAEHEE

AU - PAIK, HAERIN

AU - PARK, SUNWOO

AU - LIM, HYUNJI

AU - KIM, JUNHWAN

AU - LEE, EUN JI

AU - YIM, GA WON

AU - LEE, NARA

AU - LEE, CHEOL

AU - KIM, JAE WEON

AU - SONG, GWONHWA

AU - KIM, HEE SEUNG

N1 - Funding Information: This study was supported by grants from Seoul National University (No. 800-20180190; 800-20190437; 800-20200309; 800-20200458). Publisher Copyright: © 2021 International Institute of Anticancer Research. All rights reserved.

PY - 2021/10

Y1 - 2021/10

N2 - Background/Aim: To evaluate the role of serine protease inhibitor B11 (SERPINB11) expression as a prognostic biomarker in high-grade serous carcinoma (HGSC) and clear cell carcinoma of the ovary (CCC). Materials and Methods: We obtained tumor tissues from patients with HGSC (n=145) and CCC (n=59). We evaluated immunohistochemically the expression of SERPINB11 and investigated whether SERPINB11 expression affects platinum-resistance and the prognosis of HGSC and CCC. Results: High expression of SERPINB11 was more common in CCC than in HGSC (57.6% vs. 28.3%; p<0.01), and SEPRINB11 expression did not correlate with platinum-resistance of HGSC and CCC. High expression of SERPINB11 was associated with worse progression-free survival and overall survival with marginal significance in HGSC; no relation between SERPINB11 expression and the prognosis of CCC was found. Conclusion: SERPINB11 expression maybe a prognostic biomarker for HGSC.

AB - Background/Aim: To evaluate the role of serine protease inhibitor B11 (SERPINB11) expression as a prognostic biomarker in high-grade serous carcinoma (HGSC) and clear cell carcinoma of the ovary (CCC). Materials and Methods: We obtained tumor tissues from patients with HGSC (n=145) and CCC (n=59). We evaluated immunohistochemically the expression of SERPINB11 and investigated whether SERPINB11 expression affects platinum-resistance and the prognosis of HGSC and CCC. Results: High expression of SERPINB11 was more common in CCC than in HGSC (57.6% vs. 28.3%; p<0.01), and SEPRINB11 expression did not correlate with platinum-resistance of HGSC and CCC. High expression of SERPINB11 was associated with worse progression-free survival and overall survival with marginal significance in HGSC; no relation between SERPINB11 expression and the prognosis of CCC was found. Conclusion: SERPINB11 expression maybe a prognostic biomarker for HGSC.

KW - Clear cell

KW - High-grade serous

KW - Ovarian cancer

KW - Prognosis

KW - SERPINB11

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U2 - 10.21873/INVIVO.12547

DO - 10.21873/INVIVO.12547

M3 - Article

C2 - 34410952

AN - SCOPUS:85113842932

SN - 0258-851X

VL - 35

SP - 2647

EP - 2653

JO - In Vivo

JF - In Vivo

IS - 5

ER -

Serpinb11 expression is associated with prognosis of high-grade serous and clear cell carcinoma of the ovary

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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