Serum adiponectin, interleukin-10 levels and inflammatory markers in the metabolic syndrome

K. M. Choi, O. H. Ryu, K. W. Lee, H. Y. Kim, J. A. Seo, S. G. Kim, N. H. Kim, D. S. Choi, S. H. Baik

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99 Citations (Scopus)


We examined the association between interleukin-10 (IL-10), adiponectin levels and inflammatory markers such as interleukin-6 (IL-6) and high-sensitive C-reactive protein (hsCRP). Furthermore, the association of these anti-/pro-inflammatory cytokine levels with the metabolic syndrome was investigated. The study subjects were composed of 312 Korean individuals without diabetes. Serum adiponectin level was associated with hsCRP (r = -0.21, P < 0.001), IL-6 (r = -0.13, P < 0.05) and IL-10 (r = -0.22, P < 0.001) levels. Subjects without the metabolic syndrome showed higher adiponectin (17.03 μg/ml versus 13.85 μg/ml, P < 0.001) and IL-10 (4.74 pg/ml versus 4.34 pg/ml, P = 0.014) levels, and lower serum hsCRP (0.38 μg/ml versus 0.66 μg/ml, P = 0.001) and IL-6 (0.94 pg/ml versus 1.32 pg/ml, P = 0.009) levels compared to those with the metabolic syndrome. In multiple logistic regression analysis, the metabolic syndrome was associated with sex, age, waist circumference, systolic blood pressure, HDL cholesterol, triglyceride, fasting blood glucose and interleukin-10. Furthermore, serum adiponectin levels are associated with serum hsCRP, IL-6 and IL-10 levels. These results suggest that adiponectin might be associated with the metabolic syndrome through regulation of pro-/anti-inflammatory cytokines.

Original languageEnglish
Pages (from-to)235-240
Number of pages6
JournalDiabetes Research and Clinical Practice
Issue number2
Publication statusPublished - 2007 Feb
Externally publishedYes

Bibliographical note

Funding Information:
Dr. K.M. Choi and S.H. Baik were supported by a grant of the Korean Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (A 050463).


  • Adiponectin
  • C-reactive protein
  • Interleukin-10
  • Interleukin-6
  • Metabolic syndrome

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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