Abstract
Alzheimer's disease (AD) is characterized by the deposition of senile plaques and neurofibrillary tangles in the brain. The presence of the amyloid-β (Aβ) peptide in senile plaques seems to play a central role in the neuropathology of AD. Diagnosis of AD involves neuropsychological examinations or magnetic resonance imaging and, to date, a specific diagnostic marker indicating AD has not been found. This study analysed anti-Aβ antibodies from the serum of 153 patients with AD using an enzymelinked immunosorbent assay method. The levels of anti-Aβ antibody from patients in the control group (n = 193) were compared with those of patients with AD. Our results showed a significantly lower anti-Aβ antibody level in patients with AD than in the control group. These results showed that the anti-Aβ antibody level in serum could potentially be used to diagnose the presence of AD.
| Original language | English |
|---|---|
| Pages (from-to) | 301-306 |
| Number of pages | 6 |
| Journal | Journal of International Medical Research |
| Volume | 35 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 2007 |
| Externally published | Yes |
Keywords
- Alzheimer's disease
- Diagnostic marker
- Elderly patients
- Serum anti-amyloid-beta antibody
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
- Biochemistry, medical