TY - JOUR
T1 - Serum insulin-like growth factor (IGF)-I and IGF binding protein-3 in relation to terminal duct lobular unit involution of the normal breast in Caucasian and African American women
T2 - The Susan G. Komen Tissue Bank
AU - Oh, Hannah
AU - Pfeiffer, Ruth M.
AU - Falk, Roni T.
AU - Horne, Hisani N.
AU - Xiang, Jackie
AU - Pollak, Michael
AU - Brinton, Louise A.
AU - Storniolo, Anna Maria V.
AU - Sherman, Mark E.
AU - Gierach, Gretchen L.
AU - Figueroa, Jonine D.
N1 - Funding Information:
Key words: Insulin-Like Growth Factor I, insulin-like somatomedin peptide I, somatomedin C, IGF-I, IGFBP-3, TDLU, normal breast tissue, lobular involution Additional Supporting Information may be found in the online version of this article. Conflict of interest: The authors declare that they have no potential conflicts of interest. †G.L.G. and J.D.F. contributed equally to this work. Grant sponsor: Intramural Research Program of the National Cancer Institute; Grant number: ZIA CP010126-16; Grant sponsor: Susan G. Komen; Grant sponsor: Breast Cancer Research Foundation; Grant sponsor: Oracle Giving; Grant sponsor: Catherine Peachey Fund DOI: 10.1002/ijc.31333 History: Received 21 July 2017; Accepted 7 Feb 2018; Online 22 Feb 2018 Correspondence to: Hannah Oh, 145 Anam-Ro, Hana Science Building, Room 358, Seongbuk-Gu, Seoul, 136-713, Republic of Korea, Tel.: 182-2-3290-5678, E-mail: hannahoh@korea.ac.kr
Funding Information:
The authors thank all KTB staff and researchers. Most importantly, the authors also thank the volunteers who donated invaluable samples that made this study possible. This study was supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics of the U.S. National Cancer Institute. The Komen Tissue Bank is supported by Susan G. Komen, the Breast Cancer Research Foundation, Oracle Giving, and the Catherine Peachey Fund, Inc.
Publisher Copyright:
© 2018 UICC
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Lesser degrees of terminal duct lobular unit (TDLU) involution, as reflected by higher numbers of TDLUs and acini/TDLU, are associated with elevated breast cancer risk. In rodent models, the insulin-like growth factor (IGF) system regulates involution of the mammary gland. We examined associations of circulating IGF measures with TDLU involution in normal breast tissues among women without precancerous lesions. Among 715 Caucasian and 283 African American (AA) women who donated normal breast tissue samples to the Komen Tissue Bank between 2009 and 2012 (75% premenopausal), serum concentrations of IGF-I and binding protein (IGFBP)-3 were quantified using enzyme-linked immunosorbent assay. Hematoxilyn and eosin-stained tissue sections were assessed for numbers of TDLUs (“TDLU count”). Zero-inflated Poisson regression models with a robust variance estimator were used to estimate relative risks (RRs) for association of IGF measures (tertiles) with TDLU count by race and menopausal status, adjusting for potential confounders. AA (vs. Caucasian) women had higher age-adjusted mean levels of serum IGF-I (137 vs. 131 ng/mL, p = 0.07) and lower levels of IGFBP-3 (4165 vs. 4684 ng/mL, p < 0.0001). Postmenopausal IGFBP-3 was inversely associated with TDLU count among AA (RRT3vs.T1 = 0.49, 95% CI = 0.28–0.84, p-trend = 0.04) and Caucasian (RRT3vs.T1=0.64, 95% CI = 0.42–0.98, p-trend = 0.04) women. In premenopausal women, higher IGF-I:IGFBP-3 ratios were associated with higher TDLU count in Caucasian (RRT3vs.T1=1.33, 95% CI = 1.02–1.75, p-trend = 0.04), but not in AA (RRT3vs.T1=0.65, 95% CI = 0.42–1.00, p-trend = 0.05), women. Our data suggest a role of the IGF system, particularly IGFBP-3, in TDLU involution of the normal breast, a breast cancer risk factor, among Caucasian and AA women.
AB - Lesser degrees of terminal duct lobular unit (TDLU) involution, as reflected by higher numbers of TDLUs and acini/TDLU, are associated with elevated breast cancer risk. In rodent models, the insulin-like growth factor (IGF) system regulates involution of the mammary gland. We examined associations of circulating IGF measures with TDLU involution in normal breast tissues among women without precancerous lesions. Among 715 Caucasian and 283 African American (AA) women who donated normal breast tissue samples to the Komen Tissue Bank between 2009 and 2012 (75% premenopausal), serum concentrations of IGF-I and binding protein (IGFBP)-3 were quantified using enzyme-linked immunosorbent assay. Hematoxilyn and eosin-stained tissue sections were assessed for numbers of TDLUs (“TDLU count”). Zero-inflated Poisson regression models with a robust variance estimator were used to estimate relative risks (RRs) for association of IGF measures (tertiles) with TDLU count by race and menopausal status, adjusting for potential confounders. AA (vs. Caucasian) women had higher age-adjusted mean levels of serum IGF-I (137 vs. 131 ng/mL, p = 0.07) and lower levels of IGFBP-3 (4165 vs. 4684 ng/mL, p < 0.0001). Postmenopausal IGFBP-3 was inversely associated with TDLU count among AA (RRT3vs.T1 = 0.49, 95% CI = 0.28–0.84, p-trend = 0.04) and Caucasian (RRT3vs.T1=0.64, 95% CI = 0.42–0.98, p-trend = 0.04) women. In premenopausal women, higher IGF-I:IGFBP-3 ratios were associated with higher TDLU count in Caucasian (RRT3vs.T1=1.33, 95% CI = 1.02–1.75, p-trend = 0.04), but not in AA (RRT3vs.T1=0.65, 95% CI = 0.42–1.00, p-trend = 0.05), women. Our data suggest a role of the IGF system, particularly IGFBP-3, in TDLU involution of the normal breast, a breast cancer risk factor, among Caucasian and AA women.
KW - IGF-I
KW - IGFBP-3
KW - Insulin-Like Growth Factor I
KW - TDLU
KW - insulin-like somatomedin peptide I
KW - lobular involution
KW - normal breast tissue
KW - somatomedin C
UR - http://www.scopus.com/inward/record.url?scp=85044757674&partnerID=8YFLogxK
U2 - 10.1002/ijc.31333
DO - 10.1002/ijc.31333
M3 - Article
C2 - 29473153
AN - SCOPUS:85044757674
SN - 0020-7136
VL - 143
SP - 496
EP - 507
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 3
ER -