Serum osteoprotegerin levels are associated with inflammation and pulse wave velocity

S. M. Kim, J. Leet, O. H. Ryu, K. W. Lee, H. Y. Kim, J. A. Seo, S. G. Kim, N. H. Kim, S. H. Baik, D. S. Choi, Kyung Mook Choi

    Research output: Contribution to journalArticlepeer-review

    72 Citations (Scopus)


    Objective: We examined the association between serum osteoprotegerin (OPG) levels, systemic inflammation and arterial stiffness in normal and diabetic patients. Patients and measurements: The study subjects comprised 49 newly diagnosed diabetic patients and 72 age- and sex-matched normal glucose controls. Anthropometric parameters, blood pressure, fasting blood glucose (FBG), lipid profiles, serum OPG, high-sensitive C-reactive protein (hsCRP), interleukin-6 (IL-6) and brachial-ankle pulse wave velocity (baPWV) were measured. Results: Serum OPG levels (6.1 ± 1.4 vs. 5.4 ± 1.3 pmol/l, P = 0.011) and baPWV (1562 ± 354 vs. 1399 ± 257 cm/s, P = 0.004) were significantly higher in the diabetic group than in the normal glucose group. Serum OPG levels in normal and diabetic patients correlated significantly with systolic blood pressure (r = 0.20, P = 0.035), FBG (r = 0.30, P = 0.002), right baPWV (r = 0.22, P = 0.021), left baPWV (r = 0.26, P = 0.006), homeostasis model assessment insulin resistance (HOMA-IR) (r = 0.19, P = 0.045), IL-6 (r = 0.32, P = 0.001) and hsCRP (r = 0.21, P = 0.027) after adjusting for age and sex. Multiple regression analysis showed that serum OPG level was significantly associated with age, FBG, IL-6, systolic blood pressure, triglyceride and hsCRP (R2 = 0.299). Conclusions: In summary, serum OPG and baPWV levels are elevated in diabetic patients and serum OPG levels are significantly associated with inflammation and arterial stiffness.

    Original languageEnglish
    Pages (from-to)594-598
    Number of pages5
    JournalClinical Endocrinology
    Issue number5
    Publication statusPublished - 2005 Nov

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology


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