Sesquiterpenoids from an edible plant Petasites japonicus and their promoting effects on neurite outgrowth

Jing Xu, Feifei Ji, Xiangrong Cao, Jun Ma, Yasushi Ohizumi, Dongho Lee, Yuanqiang Guo

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


Petasites japonicus (Sieb. & Zucc.) Maxim., belonging to the Compositae family, is a perennial herb and has been consumed as a wild vegetable. Our survey on the chemical composition of P. japonicus resulted in the isolation of two new and seventeen known sesquiterpenoids. Their structures were elucidated on the basis of nuclear magnetic resonance (NMR) spectroscopic data analysis, and the absolute configurations of the new compounds were established by comparison of the calculated and experimental electronic circular dichroism (ECD) spectra. Among these isolates, compound 1 was a sesquiterpene carrying a chlorine atom, 2 processed a rare 7,9-secobakkenolide skeleton, and compounds 4, 11- 13, 15, 18, and 19 were obtained from this species for the first time. Most of these compounds showed promoting effects on neurite outgrowth from PC12 cells. These chemical and biological results provide a basis for further development and utilization of P. japonicus as a functional food.

Original languageEnglish
Pages (from-to)291-299
Number of pages9
JournalJournal of Functional Foods
Publication statusPublished - 2016 Apr 1

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China (No. 21372125 ).

Publisher Copyright:
© 2016 Elsevier Ltd.


  • ECD calculation
  • Petasites japonicus
  • Promoting effects on neurite outgrowth
  • Sesquiterpenoids

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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