Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production

Jun Gu Kim; Jin Woo Lee; Thi Phuong Linh Le; Jae Sang Han; Yong Beom Cho; Haeun Kwon; Dongho Lee; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1021/acs.jnatprod.0c01121

Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production

Jun Gu Kim, Jin Woo Lee, Thi Phuong Linh Le, Jae Sang Han, Yong Beom Cho, Haeun Kwon, Dongho Lee, Mi Kyeong Lee, Bang Yeon Hwang

Department of Biosystems and Biotechnology

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Three new guaianolide lactones (1-3) and four new 9-oxonerolidol glucosides (5-8) together with 20 known compounds were isolated from the MeOH extract of the flowers of Chrysanthemum indicum. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data along with acid hydrolysis. Of the isolates, sesquiterpenoids 1-4 and 15 and flavones 17 and 18 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 cells with IC50 values in the range 0.2-27.0 μM.

Original language	English
Pages (from-to)	562-569
Number of pages	8
Journal	Journal of Natural Products
Volume	84
Issue number	3
DOIs	https://doi.org/10.1021/acs.jnatprod.0c01121
Publication status	Published - 2021 Mar 26

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1021/acs.jnatprod.0c01121

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@article{747fa92321d4402c8190c28eb4074117,

title = "Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production",

abstract = "Three new guaianolide lactones (1-3) and four new 9-oxonerolidol glucosides (5-8) together with 20 known compounds were isolated from the MeOH extract of the flowers of Chrysanthemum indicum. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data along with acid hydrolysis. Of the isolates, sesquiterpenoids 1-4 and 15 and flavones 17 and 18 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 cells with IC50 values in the range 0.2-27.0 μM.",

author = "Kim, {Jun Gu} and Lee, {Jin Woo} and Le, {Thi Phuong Linh} and Han, {Jae Sang} and Cho, {Yong Beom} and Haeun Kwon and Dongho Lee and Lee, {Mi Kyeong} and Hwang, {Bang Yeon}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MIST) (No. 2020R1A2C1008406) and by the Korea Basic Science Institute under the R&D program (Project No. C140440) supervised by the Ministry of Science and ICT. Publisher Copyright: {\textcopyright} 2021 American Chemical Society and American Society of Pharmacognosy.",

year = "2021",

month = mar,

day = "26",

doi = "10.1021/acs.jnatprod.0c01121",

language = "English",

volume = "84",

pages = "562--569",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

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TY - JOUR

T1 - Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production

AU - Kim, Jun Gu

AU - Lee, Jin Woo

AU - Le, Thi Phuong Linh

AU - Han, Jae Sang

AU - Cho, Yong Beom

AU - Kwon, Haeun

AU - Lee, Dongho

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MIST) (No. 2020R1A2C1008406) and by the Korea Basic Science Institute under the R&D program (Project No. C140440) supervised by the Ministry of Science and ICT. Publisher Copyright: © 2021 American Chemical Society and American Society of Pharmacognosy.

PY - 2021/3/26

Y1 - 2021/3/26

N2 - Three new guaianolide lactones (1-3) and four new 9-oxonerolidol glucosides (5-8) together with 20 known compounds were isolated from the MeOH extract of the flowers of Chrysanthemum indicum. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data along with acid hydrolysis. Of the isolates, sesquiterpenoids 1-4 and 15 and flavones 17 and 18 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 cells with IC50 values in the range 0.2-27.0 μM.

AB - Three new guaianolide lactones (1-3) and four new 9-oxonerolidol glucosides (5-8) together with 20 known compounds were isolated from the MeOH extract of the flowers of Chrysanthemum indicum. Their structures were elucidated based on the interpretation of NMR, HRESIMS, and electronic circular dichroism (ECD) data along with acid hydrolysis. Of the isolates, sesquiterpenoids 1-4 and 15 and flavones 17 and 18 exhibited inhibitory effects on lipopolysaccharide (LPS)-induced nitric oxide production in RAW 264.7 cells with IC50 values in the range 0.2-27.0 μM.

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U2 - 10.1021/acs.jnatprod.0c01121

DO - 10.1021/acs.jnatprod.0c01121

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AN - SCOPUS:85103454775

SN - 0163-3864

VL - 84

SP - 562

EP - 569

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 3

ER -

Sesquiterpenoids from Chrysanthemum indicum with Inhibitory Effects on NO Production

Abstract

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