Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells

Hari Jang, Jin Woo Lee, Chul Lee, Qinghao Jin, Jeong Yeon Choi, Dongho Lee, Sang Bae Han, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

    Research output: Contribution to journalArticlepeer-review

    27 Citations (Scopus)

    Abstract

    A new oplopane-type sesquiterpenoid tussilagofarin (1) and a new chromone tussilagofarol (2), along with 18 known compounds 3-20, were isolated from the flower buds of Tussilago farfara. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and HRESIMS data. Of the isolated compounds, oplopane- and bisabolane-type sesquterpenoids 1, 8-12, 15, and 16 were found to inhibit nitric oxide production in LPS-induced RAW 264.7 cells with IC50 values of 3.5-28.5 μM.

    Original languageEnglish
    Pages (from-to)127-132
    Number of pages6
    JournalArchives of pharmacal research
    Volume39
    Issue number1
    DOIs
    Publication statusPublished - 2016 Jan 1

    Bibliographical note

    Publisher Copyright:
    © 2015 The Pharmaceutical Society of Korea.

    Keywords

    • Asteraceae
    • Nitric oxide production inhibitor
    • Oplopane-type sesquiterpenoid
    • Tussilago farfara

    ASJC Scopus subject areas

    • Drug Discovery
    • Molecular Medicine
    • Organic Chemistry

    Fingerprint

    Dive into the research topics of 'Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells'. Together they form a unique fingerprint.

    Cite this