Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells

Hari Jang; Jin Woo Lee; Chul Lee; Qinghao Jin; Jeong Yeon Choi; Dongho Lee; Sang Bae Han; Youngsoo Kim; Jin Tae Hong; Mi Kyeong Lee; Bang Yeon Hwang

doi:10.1007/s12272-015-0667-7

Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells

Hari Jang, Jin Woo Lee, Chul Lee, Qinghao Jin, Jeong Yeon Choi, Dongho Lee, Sang Bae Han, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee, Bang Yeon Hwang

Division of Biotechnology

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

A new oplopane-type sesquiterpenoid tussilagofarin (1) and a new chromone tussilagofarol (2), along with 18 known compounds 3-20, were isolated from the flower buds of Tussilago farfara. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and HRESIMS data. Of the isolated compounds, oplopane- and bisabolane-type sesquterpenoids 1, 8-12, 15, and 16 were found to inhibit nitric oxide production in LPS-induced RAW 264.7 cells with IC₅₀ values of 3.5-28.5 μM.

Original language	English
Pages (from-to)	127-132
Number of pages	6
Journal	Archives of Pharmacal Research
Volume	39
Issue number	1
DOIs	https://doi.org/10.1007/s12272-015-0667-7
Publication status	Published - 2016 Jan 1

Keywords

Asteraceae
Nitric oxide production inhibitor
Oplopane-type sesquiterpenoid
Tussilago farfara

ASJC Scopus subject areas

Drug Discovery
Molecular Medicine
Organic Chemistry

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title = "Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells",

abstract = "A new oplopane-type sesquiterpenoid tussilagofarin (1) and a new chromone tussilagofarol (2), along with 18 known compounds 3-20, were isolated from the flower buds of Tussilago farfara. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and HRESIMS data. Of the isolated compounds, oplopane- and bisabolane-type sesquterpenoids 1, 8-12, 15, and 16 were found to inhibit nitric oxide production in LPS-induced RAW 264.7 cells with IC50 values of 3.5-28.5 μM.",

keywords = "Asteraceae, Nitric oxide production inhibitor, Oplopane-type sesquiterpenoid, Tussilago farfara",

author = "Hari Jang and Lee, {Jin Woo} and Chul Lee and Qinghao Jin and Choi, {Jeong Yeon} and Dongho Lee and Han, {Sang Bae} and Youngsoo Kim and Hong, {Jin Tae} and Lee, {Mi Kyeong} and Hwang, {Bang Yeon}",

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AU - Jang, Hari

AU - Lee, Jin Woo

AU - Lee, Chul

AU - Jin, Qinghao

AU - Choi, Jeong Yeon

AU - Lee, Dongho

AU - Han, Sang Bae

AU - Kim, Youngsoo

AU - Hong, Jin Tae

AU - Lee, Mi Kyeong

AU - Hwang, Bang Yeon

PY - 2016/1/1

Y1 - 2016/1/1

N2 - A new oplopane-type sesquiterpenoid tussilagofarin (1) and a new chromone tussilagofarol (2), along with 18 known compounds 3-20, were isolated from the flower buds of Tussilago farfara. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and HRESIMS data. Of the isolated compounds, oplopane- and bisabolane-type sesquterpenoids 1, 8-12, 15, and 16 were found to inhibit nitric oxide production in LPS-induced RAW 264.7 cells with IC50 values of 3.5-28.5 μM.

AB - A new oplopane-type sesquiterpenoid tussilagofarin (1) and a new chromone tussilagofarol (2), along with 18 known compounds 3-20, were isolated from the flower buds of Tussilago farfara. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and HRESIMS data. Of the isolated compounds, oplopane- and bisabolane-type sesquterpenoids 1, 8-12, 15, and 16 were found to inhibit nitric oxide production in LPS-induced RAW 264.7 cells with IC50 values of 3.5-28.5 μM.

KW - Asteraceae

KW - Nitric oxide production inhibitor

KW - Oplopane-type sesquiterpenoid

KW - Tussilago farfara

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Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells

Abstract

Keywords

ASJC Scopus subject areas

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