Sex differences in hippocampal neuronal sensitization by nicotine in M. gerbils

Young Na Hur, Joon Lee, Seung Chan Sohn, Chung Gil Won, Hyung Ha Lee, Dong Hoon Kim, Sang Hyun Choi, Kyung Ho Shin, Boe Gwun Chun

Research output: Contribution to journalArticlepeer-review


We studied the sex different nicotine effect on evoked population spike amplitudes (ePSA) and connexin (Cx) expression in the hippocampus CA1 area of gerbils. Acute doses of nicotine bitartrate (0.5 mg/kg: NT-0.5) slightly reduced ePSA in males but markedly augmented that in females. Acute NT (5.0 mg/kg) markedly increased the ePSA in all gerbils. Unlike acute NT-0.5, repeated NT-0.5 injection (twice a day for 7 days) significantly increased the ePSA in males and slightly affected the NT-0.5 effect in females. The Cx36 and Cx43 expression levels as well as Cx expressing neuronal populations were significantly increased by repeated NT-0.5 in in both male and female gerbils, and particularly, Cx43 expression was somewhat prominent in females. These results demonstrated a sex difference with respect to the nicotine effect on hippocampal bisynaptic excitability, irrelevant to connexin expression.

Original languageEnglish
Pages (from-to)405-409
Number of pages5
JournalKorean Journal of Physiology and Pharmacology
Issue number5
Publication statusPublished - 2013 Oct


  • Connexin
  • Evoked population spike
  • Hippocampus
  • Nicotine
  • Sex difference

ASJC Scopus subject areas

  • Physiology
  • Pharmacology


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