Shape and volumetric differences in the corpus callosum between patients with major depressive disorder and healthy controls

Sekwang Lee; Sung Bom Pyun; Kwan Woo Choi; Woo Suk Tae

doi:10.30773/pi.2020.0157

Shape and volumetric differences in the corpus callosum between patients with major depressive disorder and healthy controls

Sekwang Lee, Sung Bom Pyun, Kwan Woo Choi, Woo Suk Tae

Department of Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

Objective This study aimed to investigate the morphometric differences in the corpus callosum between patients with major depressive disorder (MDD) and healthy controls and analyze their relationship to gray matter changes. Methods Twenty female MDD patients and 21 healthy controls (HCs) were included in the study. To identify the difference in the regional gray matter concentration (GMC), VBM was performed with T1 magnetic resonance imaging. The shape analysis of the corpus callosum was processed. Diffusion tensor imaging (DTI) fiber-tracking was performed to identify the regional tract pathways in the damaged corpus callosal areas. Results In the shape analysis, regional shape contractions in the rostrum and splenium were found in the MDD patients. VBM analysis showed a significantly lower white matter concentration in the genu and splenium, and a significantly lower GMC in the frontal, limbic, insular, and temporal regions of the MDD patients compared to the HCs. In DTI fiber-tracking, the fibers crossing the damaged areas of the genu, rostrum, and splenium were anatomically connected to the areas of lower GMC in MDD patients. Conclusion These findings support that major depressive disorder may be due to disturbances in multiple neuronal circuits, especially those associated with the corpus callosum.

Original language	English
Pages (from-to)	941-950
Number of pages	10
Journal	Psychiatry Investigation
Volume	17
Issue number	9
DOIs	https://doi.org/10.30773/pi.2020.0157
Publication status	Published - 2020 Sept

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2017R1D1A1B030 30280), the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2017M3C7A1079696), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R111A1A01067132), and a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R1C1C1003394). This research was also supported by a grant from the Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. K1922891).

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2017R1D1A1B030 30280), the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2017M3C7A1079696), ), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R111A1A01067132), and a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R1C1C1003394). This research was also supported by a grant from the Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. K1922891).

Publisher Copyright:
© 2019 Korean Neuropsychiatric Association.

Keywords

Corpus callosum
Magnetic resonance imaging
Major depressive disorder
Shape analysis
Voxel-based morphometry

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.30773/pi.2020.0157

Cite this

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title = "Shape and volumetric differences in the corpus callosum between patients with major depressive disorder and healthy controls",

abstract = "Objective This study aimed to investigate the morphometric differences in the corpus callosum between patients with major depressive disorder (MDD) and healthy controls and analyze their relationship to gray matter changes. Methods Twenty female MDD patients and 21 healthy controls (HCs) were included in the study. To identify the difference in the regional gray matter concentration (GMC), VBM was performed with T1 magnetic resonance imaging. The shape analysis of the corpus callosum was processed. Diffusion tensor imaging (DTI) fiber-tracking was performed to identify the regional tract pathways in the damaged corpus callosal areas. Results In the shape analysis, regional shape contractions in the rostrum and splenium were found in the MDD patients. VBM analysis showed a significantly lower white matter concentration in the genu and splenium, and a significantly lower GMC in the frontal, limbic, insular, and temporal regions of the MDD patients compared to the HCs. In DTI fiber-tracking, the fibers crossing the damaged areas of the genu, rostrum, and splenium were anatomically connected to the areas of lower GMC in MDD patients. Conclusion These findings support that major depressive disorder may be due to disturbances in multiple neuronal circuits, especially those associated with the corpus callosum.",

keywords = "Corpus callosum, Magnetic resonance imaging, Major depressive disorder, Shape analysis, Voxel-based morphometry",

author = "Sekwang Lee and Pyun, {Sung Bom} and Choi, {Kwan Woo} and Tae, {Woo Suk}",

note = "Funding Information: This work was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2017R1D1A1B030 30280), the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2017M3C7A1079696), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R111A1A01067132), and a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R1C1C1003394). This research was also supported by a grant from the Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. K1922891). Funding Information: This work was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2017R1D1A1B030 30280), the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2017M3C7A1079696), ), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R111A1A01067132), and a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R1C1C1003394). This research was also supported by a grant from the Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. K1922891). Publisher Copyright: {\textcopyright} 2019 Korean Neuropsychiatric Association.",

year = "2020",

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doi = "10.30773/pi.2020.0157",

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T1 - Shape and volumetric differences in the corpus callosum between patients with major depressive disorder and healthy controls

AU - Lee, Sekwang

AU - Pyun, Sung Bom

AU - Choi, Kwan Woo

AU - Tae, Woo Suk

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2017R1D1A1B030 30280), the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2017M3C7A1079696), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R111A1A01067132), and a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R1C1C1003394). This research was also supported by a grant from the Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. K1922891). Funding Information: This work was supported by the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2017R1D1A1B030 30280), the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No. 2017M3C7A1079696), ), a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R111A1A01067132), and a National Research Foundation of Korea (NRF) grant funded by the Korean government (MSIT) (No. 2020R1C1C1003394). This research was also supported by a grant from the Korea University Anam Hospital, Seoul, Republic of Korea (Grant No. K1922891). Publisher Copyright: © 2019 Korean Neuropsychiatric Association.

PY - 2020/9

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N2 - Objective This study aimed to investigate the morphometric differences in the corpus callosum between patients with major depressive disorder (MDD) and healthy controls and analyze their relationship to gray matter changes. Methods Twenty female MDD patients and 21 healthy controls (HCs) were included in the study. To identify the difference in the regional gray matter concentration (GMC), VBM was performed with T1 magnetic resonance imaging. The shape analysis of the corpus callosum was processed. Diffusion tensor imaging (DTI) fiber-tracking was performed to identify the regional tract pathways in the damaged corpus callosal areas. Results In the shape analysis, regional shape contractions in the rostrum and splenium were found in the MDD patients. VBM analysis showed a significantly lower white matter concentration in the genu and splenium, and a significantly lower GMC in the frontal, limbic, insular, and temporal regions of the MDD patients compared to the HCs. In DTI fiber-tracking, the fibers crossing the damaged areas of the genu, rostrum, and splenium were anatomically connected to the areas of lower GMC in MDD patients. Conclusion These findings support that major depressive disorder may be due to disturbances in multiple neuronal circuits, especially those associated with the corpus callosum.

AB - Objective This study aimed to investigate the morphometric differences in the corpus callosum between patients with major depressive disorder (MDD) and healthy controls and analyze their relationship to gray matter changes. Methods Twenty female MDD patients and 21 healthy controls (HCs) were included in the study. To identify the difference in the regional gray matter concentration (GMC), VBM was performed with T1 magnetic resonance imaging. The shape analysis of the corpus callosum was processed. Diffusion tensor imaging (DTI) fiber-tracking was performed to identify the regional tract pathways in the damaged corpus callosal areas. Results In the shape analysis, regional shape contractions in the rostrum and splenium were found in the MDD patients. VBM analysis showed a significantly lower white matter concentration in the genu and splenium, and a significantly lower GMC in the frontal, limbic, insular, and temporal regions of the MDD patients compared to the HCs. In DTI fiber-tracking, the fibers crossing the damaged areas of the genu, rostrum, and splenium were anatomically connected to the areas of lower GMC in MDD patients. Conclusion These findings support that major depressive disorder may be due to disturbances in multiple neuronal circuits, especially those associated with the corpus callosum.

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KW - Magnetic resonance imaging

KW - Major depressive disorder

KW - Shape analysis

KW - Voxel-based morphometry

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Shape and volumetric differences in the corpus callosum between patients with major depressive disorder and healthy controls

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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