Shape deformation in the brainstem of medication-naïve female patients with major depressive disorder

Kwan Woo Choi; Soonwook Kwon; Sung Bom Pyun; Woo Suk Tae

doi:10.30773/pi.2020.0025

Shape deformation in the brainstem of medication-naïve female patients with major depressive disorder

Kwan Woo Choi, Soonwook Kwon, Sung Bom Pyun, Woo Suk Tae

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Objective Although neuroimaging studies have shown volumetric reductions, such as the anterior cingulate, prefrontal cortices, and hippocampus in patients with major depressive disorder (MDD), few studies have investigated the volume of or shape alterations in the subcortical regions and the brainstem. We hypothesized that medication-naïve female adult patients with MDD might present with shape and volume alterations in the subcortical regions, including the brainstem, compared to healthy controls (HCs). Methods A total of 20 medication-naïve female patients with MDD and 21 age-matched female HCs, underwent 3D T1-weighted structural magnetic resonance scanning. We analyzed the volumes of each subcortical region and each brainstem region, including the midbrain, pons, and medulla oblongata. We also performed surface-based vertex analyses on the subcortical areas and brainstem. Results Female patients with MDD showed non-significant volumetric differences in the subcortical regions, whole brainstem, and each brainstem region compared to the HCs. However, in the surface-based vertex analyses, significant shape contractions were observed in both cerebellar peduncles located on the lateral wall of the posterior brainstem [threshold-free cluster enhancement, corrected for family-wise error (FWE) at p<0.05] in patients with MDD. Conclusion We revealed shape alterations in the posterior brainstem in female patients with MDD.

Original language	English
Pages (from-to)	465-474
Number of pages	10
Journal	Psychiatry Investigation
Volume	17
Issue number	5
DOIs	https://doi.org/10.30773/pi.2020.0025
Publication status	Published - 2020 May

Bibliographical note

Funding Information:
This research was supported the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2017M3C7A1079696), and by the Research Program to Solve Social Issues of the NRF of Korea funded by the Ministry of Science and ICT (MSIT) (NRF-2017R1D-1A1B03030280). This work was also supported and funded by the NRF grant funded by the Korea government (MSIT) (NRF-2020R1C1C1003394), and by Korea University (K1922891). The NRF of Korea and Korea University had no further role in study design; collection, analysis, and interpretation of data; writing of the report; or in the decision to submit the study for publication.

Funding Information:
This research was supported the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2017M3C7A1079696), and by the Research Program to Solve Social Issues of the NRF of Korea funded by the Ministry of Science and ICT (MSIT) (NRF-2017R1D-1A1B03030280). This work was also supported and funded by the NRF grant funded by the Korea government (MSIT) (NRF-2020R1C1C1003394), and by Korea University (K1922891).

Publisher Copyright:
© 2020 Korean Neuropsychiatric Association.

Keywords

Brainstem
Female depression
Magnetic resonance imaging
Major depressive disorder
Subcortical regions

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.30773/pi.2020.0025

Cite this

@article{6ef5dc17e97243fdb1afd08866503b80,

title = "Shape deformation in the brainstem of medication-na{\"i}ve female patients with major depressive disorder",

abstract = "Objective Although neuroimaging studies have shown volumetric reductions, such as the anterior cingulate, prefrontal cortices, and hippocampus in patients with major depressive disorder (MDD), few studies have investigated the volume of or shape alterations in the subcortical regions and the brainstem. We hypothesized that medication-na{\"i}ve female adult patients with MDD might present with shape and volume alterations in the subcortical regions, including the brainstem, compared to healthy controls (HCs). Methods A total of 20 medication-na{\"i}ve female patients with MDD and 21 age-matched female HCs, underwent 3D T1-weighted structural magnetic resonance scanning. We analyzed the volumes of each subcortical region and each brainstem region, including the midbrain, pons, and medulla oblongata. We also performed surface-based vertex analyses on the subcortical areas and brainstem. Results Female patients with MDD showed non-significant volumetric differences in the subcortical regions, whole brainstem, and each brainstem region compared to the HCs. However, in the surface-based vertex analyses, significant shape contractions were observed in both cerebellar peduncles located on the lateral wall of the posterior brainstem [threshold-free cluster enhancement, corrected for family-wise error (FWE) at p<0.05] in patients with MDD. Conclusion We revealed shape alterations in the posterior brainstem in female patients with MDD.",

keywords = "Brainstem, Female depression, Magnetic resonance imaging, Major depressive disorder, Subcortical regions",

author = "Choi, {Kwan Woo} and Soonwook Kwon and Pyun, {Sung Bom} and Tae, {Woo Suk}",

note = "Funding Information: This research was supported the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2017M3C7A1079696), and by the Research Program to Solve Social Issues of the NRF of Korea funded by the Ministry of Science and ICT (MSIT) (NRF-2017R1D-1A1B03030280). This work was also supported and funded by the NRF grant funded by the Korea government (MSIT) (NRF-2020R1C1C1003394), and by Korea University (K1922891). The NRF of Korea and Korea University had no further role in study design; collection, analysis, and interpretation of data; writing of the report; or in the decision to submit the study for publication. Funding Information: This research was supported the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2017M3C7A1079696), and by the Research Program to Solve Social Issues of the NRF of Korea funded by the Ministry of Science and ICT (MSIT) (NRF-2017R1D-1A1B03030280). This work was also supported and funded by the NRF grant funded by the Korea government (MSIT) (NRF-2020R1C1C1003394), and by Korea University (K1922891). Publisher Copyright: {\textcopyright} 2020 Korean Neuropsychiatric Association.",

year = "2020",

month = may,

doi = "10.30773/pi.2020.0025",

language = "English",

volume = "17",

pages = "465--474",

journal = "Psychiatry Investigation",

issn = "1738-3684",

publisher = "Korean Neuropsychiatric Association",

number = "5",

}

TY - JOUR

T1 - Shape deformation in the brainstem of medication-naïve female patients with major depressive disorder

AU - Choi, Kwan Woo

AU - Kwon, Soonwook

AU - Pyun, Sung Bom

AU - Tae, Woo Suk

N1 - Funding Information: This research was supported the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2017M3C7A1079696), and by the Research Program to Solve Social Issues of the NRF of Korea funded by the Ministry of Science and ICT (MSIT) (NRF-2017R1D-1A1B03030280). This work was also supported and funded by the NRF grant funded by the Korea government (MSIT) (NRF-2020R1C1C1003394), and by Korea University (K1922891). The NRF of Korea and Korea University had no further role in study design; collection, analysis, and interpretation of data; writing of the report; or in the decision to submit the study for publication. Funding Information: This research was supported the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science, ICT and Future Planning (NRF-2017M3C7A1079696), and by the Research Program to Solve Social Issues of the NRF of Korea funded by the Ministry of Science and ICT (MSIT) (NRF-2017R1D-1A1B03030280). This work was also supported and funded by the NRF grant funded by the Korea government (MSIT) (NRF-2020R1C1C1003394), and by Korea University (K1922891). Publisher Copyright: © 2020 Korean Neuropsychiatric Association.

PY - 2020/5

Y1 - 2020/5

N2 - Objective Although neuroimaging studies have shown volumetric reductions, such as the anterior cingulate, prefrontal cortices, and hippocampus in patients with major depressive disorder (MDD), few studies have investigated the volume of or shape alterations in the subcortical regions and the brainstem. We hypothesized that medication-naïve female adult patients with MDD might present with shape and volume alterations in the subcortical regions, including the brainstem, compared to healthy controls (HCs). Methods A total of 20 medication-naïve female patients with MDD and 21 age-matched female HCs, underwent 3D T1-weighted structural magnetic resonance scanning. We analyzed the volumes of each subcortical region and each brainstem region, including the midbrain, pons, and medulla oblongata. We also performed surface-based vertex analyses on the subcortical areas and brainstem. Results Female patients with MDD showed non-significant volumetric differences in the subcortical regions, whole brainstem, and each brainstem region compared to the HCs. However, in the surface-based vertex analyses, significant shape contractions were observed in both cerebellar peduncles located on the lateral wall of the posterior brainstem [threshold-free cluster enhancement, corrected for family-wise error (FWE) at p<0.05] in patients with MDD. Conclusion We revealed shape alterations in the posterior brainstem in female patients with MDD.

AB - Objective Although neuroimaging studies have shown volumetric reductions, such as the anterior cingulate, prefrontal cortices, and hippocampus in patients with major depressive disorder (MDD), few studies have investigated the volume of or shape alterations in the subcortical regions and the brainstem. We hypothesized that medication-naïve female adult patients with MDD might present with shape and volume alterations in the subcortical regions, including the brainstem, compared to healthy controls (HCs). Methods A total of 20 medication-naïve female patients with MDD and 21 age-matched female HCs, underwent 3D T1-weighted structural magnetic resonance scanning. We analyzed the volumes of each subcortical region and each brainstem region, including the midbrain, pons, and medulla oblongata. We also performed surface-based vertex analyses on the subcortical areas and brainstem. Results Female patients with MDD showed non-significant volumetric differences in the subcortical regions, whole brainstem, and each brainstem region compared to the HCs. However, in the surface-based vertex analyses, significant shape contractions were observed in both cerebellar peduncles located on the lateral wall of the posterior brainstem [threshold-free cluster enhancement, corrected for family-wise error (FWE) at p<0.05] in patients with MDD. Conclusion We revealed shape alterations in the posterior brainstem in female patients with MDD.

KW - Brainstem

KW - Female depression

KW - Magnetic resonance imaging

KW - Major depressive disorder

KW - Subcortical regions

UR - http://www.scopus.com/inward/record.url?scp=85085284679&partnerID=8YFLogxK

U2 - 10.30773/pi.2020.0025

DO - 10.30773/pi.2020.0025

M3 - Article

AN - SCOPUS:85085284679

SN - 1738-3684

VL - 17

SP - 465

EP - 474

JO - Psychiatry Investigation

JF - Psychiatry Investigation

IS - 5

ER -

Shape deformation in the brainstem of medication-naïve female patients with major depressive disorder

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this