Shogaol overcomes TRAIL resistance in colon cancer cells via inhibiting of survivin

Jung Soon Hwang, Hai Chon Lee, Sang Cheul Oh, Dae Hee Lee, Ki Han Kwon

    Research output: Contribution to journalArticlepeer-review

    23 Citations (Scopus)

    Abstract

    In this study, we showed the ability of representative shogaol, which as a major component of ginger, to overcome TRAIL resistance by increasing apoptosis in colon cancer cells. Shogaol increased death receptor 5 (DR5) levels. Furthermore, shogaol decreased the expression level of antiapoptotic proteins (survivin and Bcl-2) and increased pro-apoptotic protein, Bax. Shogaol treatment induced apoptosis and a robust reduction in the levels of the antiapoptotic protein survivin but did not affect the levels of many other apoptosis regulators. Moreover, knockdown of survivin sensitized colon cancer cells to resistant of TRAIL-induced apoptosis. Therefore, we showed the functions of shogaol as a sensitizing agent to induce cell death of TRAIL-resistant colon cancer cells. This study gives rise to the possibility of applying shogaol as an antitumor agent that can be used for the purpose of combination treatment with TRAIL in TRAIL-resistant colon tumor therapy.

    Original languageEnglish
    Pages (from-to)8819-8829
    Number of pages11
    JournalTumor Biology
    Volume36
    Issue number11
    DOIs
    Publication statusPublished - 2015 Nov 1

    Bibliographical note

    Publisher Copyright:
    © 2015, International Society of Oncology and BioMarkers (ISOBM).

    Keywords

    • Apoptosis
    • Death receptor 5 (DR5)
    • Shogaol
    • Survivin
    • Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)

    ASJC Scopus subject areas

    • Cancer Research

    Fingerprint

    Dive into the research topics of 'Shogaol overcomes TRAIL resistance in colon cancer cells via inhibiting of survivin'. Together they form a unique fingerprint.

    Cite this