Short report: Emergence of new alleles of the MSP-3́ gene in Plasmodium vivax isolates from Korea

Deok Hwa Nam, Jun Seo Oh, Myoung Hyun Nam, Hae Chul Park, Chae Seung Lim, Won Ja Lee, Jetsumon Sattabongkot, Terry A. Klein, Francisco J. Ayala

    Research output: Contribution to journalArticlepeer-review

    7 Citations (Scopus)

    Abstract

    Nucleotide sequence analysis of the Plasmodium vivax PvMSP-3α gene was conducted on blood from 143 malaria patients admitted to Korea University Medical Center from 1996 to 2007 in the Republic of Korea (ROK). From 1996 to 2002, the PvMSP-3α alleles were of two types, SKOR-67 (2.53 kb) and SKOR-69 (1.78 kb), which differed in length and amino acid sequence. Two new variants with similar size to SKOR-67 were first observed in 2002 and in 2006-2007 accounted for nearly 50% (25/51) of the sampled isolates. The new variants had the same amino acid sequence as SKOR-69 in the N-terminal region, but in Blocks I and II and in the C-terminal region, they were similar to previously reported isolates from Thailand, Papua New Guinea, India, Brazil, and Ecuador strains.

    Original languageEnglish
    Pages (from-to)522-524
    Number of pages3
    JournalAmerican Journal of Tropical Medicine and Hygiene
    Volume82
    Issue number4
    DOIs
    Publication statusPublished - 2010 Apr

    ASJC Scopus subject areas

    • Parasitology
    • Infectious Diseases
    • Virology

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