TY - JOUR
T1 - Short-term exposure to dim light at night disrupts rhythmic behaviors and causes neurodegeneration in fly models of tauopathy and Alzheimer's disease
AU - Kim, Mari
AU - Subramanian, Manivannan
AU - Cho, Yun Ho
AU - Kim, Gye Hyeong
AU - Lee, Eunil
AU - Park, Joong Jean
N1 - Funding Information:
This study was supported by grants from the National Research Foundation of Korea (NRF-2012M3A9B6055351 and NRF-2017R1D1A1B03033648 to J-J.P; NRF-2016R1D1A102937060 to M.K. and E.L.) and the Korean Environmental Industry and Technology Institute (KEITI) through environmental health action program (EHAP) (RE201704026 to M.K.) funded by Korea Ministry of Environment.
Funding Information:
This study was supported by grants from the National Research Foundation of Korea ( NRF-2012M3A9B6055351 and NRF-2017R1D1A1B03033648 to J-J.P; NRF-2016R1D1A102937060 to M.K. and E.L.) and the Korean Environmental Industry and Technology Institute (KEITI) through environmental health action program (EHAP) ( RE201704026 to M.K.) funded by Korea Ministry of Environment .
Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2018/1/8
Y1 - 2018/1/8
N2 - The accumulation and aggregation of phosphorylated tau proteins in the brain are the hallmarks for the onset of Alzheimer's disease (AD). In addition, disruptions in circadian rhythms (CRs) with altered sleep-wake cycles, dysregulation of locomotion, and increased memory defects have been reported in patients with AD. Drosophila flies that have an overexpression of human tau protein in neurons exhibit most of the symptoms of human patients with AD, including locomotion defects and neurodegeneration. Using the fly model for tauopathy/AD, we investigated the effects of an exposure to dim light at night on AD symptoms. We used a light intensity of 10 lux, which is considered the lower limit of light pollution in many countries. After the tauopathy flies were exposed to the dim light at night for 3 days, the flies showed disrupted CRs, altered sleep-wake cycles due to increased pTau proteins and neurodegeneration, in the brains of the AD flies. The results indicate that the nighttime exposure of tauopathy/AD model Drosophila flies to dim light disrupted CR and sleep-wake behavior and promoted neurodegeneration.
AB - The accumulation and aggregation of phosphorylated tau proteins in the brain are the hallmarks for the onset of Alzheimer's disease (AD). In addition, disruptions in circadian rhythms (CRs) with altered sleep-wake cycles, dysregulation of locomotion, and increased memory defects have been reported in patients with AD. Drosophila flies that have an overexpression of human tau protein in neurons exhibit most of the symptoms of human patients with AD, including locomotion defects and neurodegeneration. Using the fly model for tauopathy/AD, we investigated the effects of an exposure to dim light at night on AD symptoms. We used a light intensity of 10 lux, which is considered the lower limit of light pollution in many countries. After the tauopathy flies were exposed to the dim light at night for 3 days, the flies showed disrupted CRs, altered sleep-wake cycles due to increased pTau proteins and neurodegeneration, in the brains of the AD flies. The results indicate that the nighttime exposure of tauopathy/AD model Drosophila flies to dim light disrupted CR and sleep-wake behavior and promoted neurodegeneration.
KW - Alzheimer's disease (AD)
KW - Circadian rhythm (CR)
KW - Dim light at night (dLAN)
KW - Drosophila melanogaster
KW - Neurodegeneration
KW - Sleep
UR - http://www.scopus.com/inward/record.url?scp=85037633722&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2017.12.021
DO - 10.1016/j.bbrc.2017.12.021
M3 - Article
C2 - 29217196
AN - SCOPUS:85037633722
SN - 0006-291X
VL - 495
SP - 1722
EP - 1729
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -