Sideroxylin (Callistemon lanceolatus) suppressed cell proliferation and increased apoptosis in ovarian cancer cells accompanied by mitochondrial dysfunction, the generation of reactive oxygen species, and an increase of lipid peroxidation

Sunwoo Park, Whasun Lim, Wonsik Jeong, Fuller W. Bazer, Dongho Lee, Gwonhwa Song

    Research output: Contribution to journalArticlepeer-review

    19 Citations (Scopus)

    Abstract

    Sideroxylin is a C-methylated flavone isolated from Callistemon lanceolatus and exerts antimicrobial activity against Staphylococcus aureus. However, the anticancer effects of sideroxylin and its intracellular signaling mechanisms have not yet been identified. Results of our study showed that sideroxylin decreased cell proliferation and increased apoptosis, causing DNA fragmentation, depolarization of the mitochondrial membrane, the generation of reactive oxygen species, and an increase of lipid peroxidation in ovarian cancer cells (ES2 and OV90 cells). Additionally, sideroxylin activated the phosphorylation of ERK1/2, JNK, P38, and MAPK proteins and the use of LY294002, U0126, SB203580, and SP600125 to block their phosphorylation, respectively, in ES2 and OV90 cells. Collectively, the results of present study indicated that sideroxylin was a novel therapeutic agent to combat the proliferation of ovarian cancer cells through the induction of mitochondrial dysfunction and the activation of PI3 K and MAPK signal transduction.

    Original languageEnglish
    Pages (from-to)8597-8604
    Number of pages8
    JournalJournal of Cellular Physiology
    Volume233
    Issue number11
    DOIs
    Publication statusPublished - 2018 Nov

    Bibliographical note

    Funding Information:
    Korea Health Technology R&D Project; Korea Health Industry Development Institute funded by the Ministry of Health & Welfare, Republic of Korea, Grant numbers: HI15C0810, HI17C0929

    Publisher Copyright:
    © 2018 Wiley Periodicals, Inc.

    Keywords

    • Callistemon lanceolatus
    • apoptosis
    • ovarian cancer
    • sideroxylin
    • signal transduction

    ASJC Scopus subject areas

    • Physiology
    • Clinical Biochemistry
    • Cell Biology

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