@article{ee4bec6238a74823a4bcfc53b84579df,
title = "Significant circulation of influenza B viruses mismatching the recommended vaccine-lineage in South Korea, 2007–2014",
abstract = "We aimed to characterize the lineages of influenza B viruses obtained from clinical specimens during the 2007–2014 seasons in South Korea. RT-PCR for the partial hemagglutinin gene of influenza B virus was performed on laboratory-confirmed influenza B samples from the 2007–2008 season to 2013–2014 season. A phylogenetic tree was generated, and current influenza vaccine strains for the Northern Hemisphere were used as representative strains of Victoria and Yamagata lineages. A total of 571 influenza B virus sequences were analyzed. During the 2009–2010 season, most of the circulating influenza B viruses matched the vaccine strain; 91.0% (91/100) of viruses belonged to the Victoria lineage. In the 2007–2008, 2011–2012, and 2013–2014 seasons, co-circulation of each influenza B lineage was found with a match ratio to the vaccine strain of 53.2% (42/79), 40.9% (63/154), and 58.3% (134/230), respectively. Overall, 41.7% (238/571) of the circulating influenza B viruses belonged to the lineage mismatching the vaccine strain. During the seven influenza seasons, influenza B epidemics were substantial in four seasons in South Korea. Significant mismatches of the vaccine and lineage of the circulating influenza B viruses were found. The current trivalent influenza vaccine may not be fully suitable for effective protection against influenza B.",
keywords = "Epidemiology, Influenza B virus",
author = "Noh, {Ji Yun} and Choi, {Won Suk} and Song, {Joon Young} and Lee, {Han Sol} and Sooyeon Lim and Jacob Lee and Seo, {Yu Bin} and Lee, {Jin Soo} and Wie, {Seong Heon} and Jeong, {Hye Won} and Heo, {Jung Yeon} and Kim, {Young Keun} and Park, {Kyung Hwa} and Kim, {Shin Woo} and Lee, {Sun Hee} and Lee, {Jung Hwa} and Kim, {Dong Hyun} and Woo, {Sung Il} and Lim, {Chae Seung} and Cho, {Kyung Soon} and Cheong, {Hee Jin} and Kim, {Woo Joo}",
note = "Funding Information: This work was supported by a grant of the TEPIK (Transgovernmental Enterprise for Pandemic Influenza in Korea), which is a part of the Korea Healthcare Technology R&D Project by Ministry of Health & Welfare, Republic of Korea (Grant no.: A103001 ). Funding for this study was also provided by GlaxoSmithKline Biologicals SA [Study 201195]. GlaxoSmithKline Biologicals SA was provided the opportunity to review a preliminary version of this manuscript for factual accuracy but the authors are solely responsible for final content and interpretation. The authors received no financial support or other form of compensation related to the development of the manuscript. Funding Information: This work was supported by a grant of the TEPIK (Transgovernmental Enterprise for Pandemic Influenza in Korea), which is a part of the Korea Healthcare Technology R&D Project by Ministry of Health & Welfare, Republic of Korea (Grant no.: A103001). Funding for this study was also provided by GlaxoSmithKline Biologicals SA [Study 201195]. GlaxoSmithKline Biologicals SA was provided the opportunity to review a preliminary version of this manuscript for factual accuracy but the authors are solely responsible for final content and interpretation. The authors received no financial support or other form of compensation related to the development of the manuscript. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
year = "2018",
month = aug,
day = "23",
doi = "10.1016/j.vaccine.2018.07.021",
language = "English",
volume = "36",
pages = "5304--5308",
journal = "Vaccine",
issn = "0264-410X",
publisher = "Elsevier BV",
number = "35",
}
