Significant circulation of influenza B viruses mismatching the recommended vaccine-lineage in South Korea, 2007–2014

Ji Yun Noh, Won Suk Choi, Joon Young Song, Han Sol Lee, Sooyeon Lim, Jacob Lee, Yu Bin Seo, Jin Soo Lee, Seong Heon Wie, Hye Won Jeong, Jung Yeon Heo, Young Keun Kim, Kyung Hwa Park, Shin Woo Kim, Sun Hee Lee, Jung Hwa Lee, Dong Hyun Kim, Sung Il Woo, Chae Seung Lim, Kyung Soon ChoHee Jin Cheong, Woo Joo Kim

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)


We aimed to characterize the lineages of influenza B viruses obtained from clinical specimens during the 2007–2014 seasons in South Korea. RT-PCR for the partial hemagglutinin gene of influenza B virus was performed on laboratory-confirmed influenza B samples from the 2007–2008 season to 2013–2014 season. A phylogenetic tree was generated, and current influenza vaccine strains for the Northern Hemisphere were used as representative strains of Victoria and Yamagata lineages. A total of 571 influenza B virus sequences were analyzed. During the 2009–2010 season, most of the circulating influenza B viruses matched the vaccine strain; 91.0% (91/100) of viruses belonged to the Victoria lineage. In the 2007–2008, 2011–2012, and 2013–2014 seasons, co-circulation of each influenza B lineage was found with a match ratio to the vaccine strain of 53.2% (42/79), 40.9% (63/154), and 58.3% (134/230), respectively. Overall, 41.7% (238/571) of the circulating influenza B viruses belonged to the lineage mismatching the vaccine strain. During the seven influenza seasons, influenza B epidemics were substantial in four seasons in South Korea. Significant mismatches of the vaccine and lineage of the circulating influenza B viruses were found. The current trivalent influenza vaccine may not be fully suitable for effective protection against influenza B.

Original languageEnglish
Pages (from-to)5304-5308
Number of pages5
Issue number35
Publication statusPublished - 2018 Aug 23


  • Epidemiology
  • Influenza B virus

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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