Significant inverse associations of serum n-6 fatty acids with plasma plasminogen activator inhibitor-1

Sunghee Lee, J. David Curb, Takashi Kadowaki, Rhobert W. Evans, Katsuyuki Miura, Tomoko Takamiya, Chol Shin, Aiman El-Saed, Jina Choo, Akira Fujiyoshi, Teruo Otake, Sayaka Kadowaki, Todd Seto, Kamal Masaki, Daniel Edmundowicz, Hirotsugu Ueshima, Lewis H. Kuller, Akira Sekikawa

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Epidemiological studies suggested that n-6 fatty acids, especially linoleic acid (LA), have beneficial effects on CHD, whereas some in vitro studies have suggested that n-6 fatty acids, specifically arachidonic acid (AA), may have harmful effects. We examined the association of serum n-6 fatty acids with plasminogen activator inhibitor-1 (PAI-1). A population-based cross-sectional study recruited 926 randomly selected men aged 40-49 years without CVD during 2002-2006 (310 Caucasian, 313 Japanese and 303 Japanese-American men). Plasma PAI-1 was analysed in free form, both active and latent. Serum fatty acids were measured with gas-capillary liquid chromatography. To examine the association between total n-6 fatty acids (including LA and AA) and PAI-1, multivariate regression models were used. After adjusting for confounders, total n-6 fatty acids, LA and AA, were inversely and significantly associated with PAI-1 levels. These associations were consistent across three populations. Among 915 middle-aged men, serum n-6 fatty acids had significant inverse associations with PAI-1.

Original languageEnglish
Pages (from-to)567-572
Number of pages6
JournalBritish Journal of Nutrition
Issue number4
Publication statusPublished - 2012 Feb 28


  • Fatty acids
  • Linoleic acid
  • Plasminogen activator inhibitor-1

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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