Simple measurement of spinal cord evoked potential: A valuable data source in the rat spinal cord injury model

Jong Pil Park; Ki Jeong Kim; Ji Hoon Phi; Chul Kee Park; Jong Hoon Kim; Hyo Jin Kang; Dohun Lee; Kyu Hyun Han; Kyu Chang Wang; Sun Ha Paek

doi:10.1016/j.jocn.2006.10.007

Simple measurement of spinal cord evoked potential: A valuable data source in the rat spinal cord injury model

Jong Pil Park, Ki Jeong Kim, Ji Hoon Phi, Chul Kee Park, Jong Hoon Kim, Hyo Jin Kang, Dohun Lee, Kyu Hyun Han, Kyu Chang Wang, Sun Ha Paek

Department of Biotechnology

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Measurement of spinal cord evoked potentials (SCEPs) is proposed as a means of predicting locomotion outcome in the rat spinal cord injury (SCI) model. Using 55 rats, three reproducible peak waves (waves I, II and III) were observed during stimulation at the C7 level with recording at the L1 epidural space. Hemisection at the T13 level showed three wave loss patterns: wave III loss only, loss of both wave II and III, and loss of all three waves. Defining an ideal SCI model as establishment of stable monoparesis or paraparesis, all animals in the wave II-III loss group showed favorable results. Histological data and electrophysiological properties allowed reasonable assumptions of wave origin: wave I from extrapyramidal tracts, wave II from the ventral corticospinal tract, and wave III from the dorsal corticospinal tract. Complete destruction of pyramidal tracts in both dorsal and ventral fibers was essential for long-term impairment of locomotion.

Original language	English
Pages (from-to)	1099-1105
Number of pages	7
Journal	Journal of Clinical Neuroscience
Volume	14
Issue number	11
DOIs	https://doi.org/10.1016/j.jocn.2006.10.007
Publication status	Published - 2007 Nov

Bibliographical note

Funding Information:
This work was partially supported by a grant from the Seoul National University Hospital, Clinical Research Institute.

Keywords

Corticospinal tract
Hemisection
Locomotion
Rat spinal cord injury model
Spinal cord evoked potential

ASJC Scopus subject areas

Surgery
Neurology
Clinical Neurology
Physiology (medical)

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10.1016/j.jocn.2006.10.007

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title = "Simple measurement of spinal cord evoked potential: A valuable data source in the rat spinal cord injury model",

abstract = "Measurement of spinal cord evoked potentials (SCEPs) is proposed as a means of predicting locomotion outcome in the rat spinal cord injury (SCI) model. Using 55 rats, three reproducible peak waves (waves I, II and III) were observed during stimulation at the C7 level with recording at the L1 epidural space. Hemisection at the T13 level showed three wave loss patterns: wave III loss only, loss of both wave II and III, and loss of all three waves. Defining an ideal SCI model as establishment of stable monoparesis or paraparesis, all animals in the wave II-III loss group showed favorable results. Histological data and electrophysiological properties allowed reasonable assumptions of wave origin: wave I from extrapyramidal tracts, wave II from the ventral corticospinal tract, and wave III from the dorsal corticospinal tract. Complete destruction of pyramidal tracts in both dorsal and ventral fibers was essential for long-term impairment of locomotion.",

keywords = "Corticospinal tract, Hemisection, Locomotion, Rat spinal cord injury model, Spinal cord evoked potential",

author = "Park, {Jong Pil} and Kim, {Ki Jeong} and Phi, {Ji Hoon} and Park, {Chul Kee} and Kim, {Jong Hoon} and Kang, {Hyo Jin} and Dohun Lee and Han, {Kyu Hyun} and Wang, {Kyu Chang} and Paek, {Sun Ha}",

note = "Funding Information: This work was partially supported by a grant from the Seoul National University Hospital, Clinical Research Institute.",

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doi = "10.1016/j.jocn.2006.10.007",

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AU - Kim, Jong Hoon

AU - Kang, Hyo Jin

AU - Lee, Dohun

AU - Han, Kyu Hyun

AU - Wang, Kyu Chang

AU - Paek, Sun Ha

N1 - Funding Information: This work was partially supported by a grant from the Seoul National University Hospital, Clinical Research Institute.

PY - 2007/11

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N2 - Measurement of spinal cord evoked potentials (SCEPs) is proposed as a means of predicting locomotion outcome in the rat spinal cord injury (SCI) model. Using 55 rats, three reproducible peak waves (waves I, II and III) were observed during stimulation at the C7 level with recording at the L1 epidural space. Hemisection at the T13 level showed three wave loss patterns: wave III loss only, loss of both wave II and III, and loss of all three waves. Defining an ideal SCI model as establishment of stable monoparesis or paraparesis, all animals in the wave II-III loss group showed favorable results. Histological data and electrophysiological properties allowed reasonable assumptions of wave origin: wave I from extrapyramidal tracts, wave II from the ventral corticospinal tract, and wave III from the dorsal corticospinal tract. Complete destruction of pyramidal tracts in both dorsal and ventral fibers was essential for long-term impairment of locomotion.

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KW - Locomotion

KW - Rat spinal cord injury model

KW - Spinal cord evoked potential

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Simple measurement of spinal cord evoked potential: A valuable data source in the rat spinal cord injury model

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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