Abstract
The purpose of this study was to evaluate 64Cu-labeled hexadecyl-1,4,7,10-tetraazacyclododecane-tetraacetic acid-benzoate (64Cu-DOTA-HB) (1) as positron emission tomography (PET) radiotracer for stem cell imaging. Hexadecyl-DOTA-benzoate (DOTA-HB) (2) was efficiently labeled with 64Cu (>99%), and cell labeling efficiency with adipose-derived stem cells (ADSCs) was over 50%. Labeling with 1 did not compromise cell viability. In the PET imaging, intramuscularly transplanted 1-labeled ADSCs were monitored for 18 h in normal rat heart. These results indicate that 1 can be utilized as a promising radiotracer for monitoring of transplanted stem cells.
Original language | English |
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Pages (from-to) | 528-530 |
Number of pages | 3 |
Journal | ACS Medicinal Chemistry Letters |
Volume | 6 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2015 May 14 |
Keywords
- Adipose-derived stem cells
- PET
- copper-64
- hexadecyl benzoate
- radiotracer
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry