Abstract
In this study, we found a simple surface biofunctionalization of biphasic calcium phosphate (BCP) based on the high affinity between alendronate and the calcium ions of BCP, and the strong interaction between heparin and bone morphogenic protein-2 (BMP-2). The biofunctionalized BCP did not be precipitated well and display a remarkable enhancement of osteogenic activity of human adipose-derived stem cells by showing increased alkaline phosphatase (ALP), calcium deposition and osteogenic-related genes (i.e., Runx-2, ALP, osteocalcin, and osteopontin), and bone regeneration in the calvarial defect model. Therefore, this simple surface technique can be used to easily functionalize various calcium phosphates.
| Original language | English |
|---|---|
| Pages (from-to) | 220-228 |
| Number of pages | 9 |
| Journal | Journal of Industrial and Engineering Chemistry |
| Volume | 68 |
| DOIs | |
| Publication status | Published - 2018 Dec 25 |
Bibliographical note
Funding Information:This research was supported by the Bio & Medical Technology Development Program of the NRF funded by the Korean government, MSIP (NRF-2017M3A9B3063640) and by the Chung-Ang University Research Grants in 2017.
Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the NRF funded by the Korean government , MSIP (NRF- 2017M3A9B3063640 ) and by the Chung-Ang University Research Grants in 2017.
Publisher Copyright:
© 2018 The Korean Society of Industrial and Engineering Chemistry
Keywords
- Alendronate
- Biphasic calcium phosphate
- Heparin
- Osteogenesis
- Surface biofunctionalization
ASJC Scopus subject areas
- General Chemical Engineering