Simulated moving bed multiobjective optimization using standing wave design and genetic algorithm

Ki Bong Lee, Rahul B. Kasat, Geoffrey B. Cox, Nien Hwa Linda Wang

Research output: Contribution to journalArticlepeer-review

81 Citations (Scopus)


Multiobjective optimization of simulated moving bed systems for chiral separations is studied by incorporating standing wave design into the nondominated sorting genetic algorithm with jumping genes. It allows simultaneous optimization of seven system, and five operating parameters to show the trade-off between productivity, desorbent requirement (DR), and yield. If pressure limit, product purity, and yield are fixed, higher productivity can be obtained at a cost of higher DR. If yield is not fixed, it can be sacrificed to achieve higher productivity or vice versa. Short zones and high feed concentration favor high productivity, whereas long zones favor high yield and low DR, At fixed product purity and yield, increasing the pressure limit allows the use of smaller particles to increase productivity and to decrease DR. The performance of low-pressure simulated moving bed can be improved significantly by using shorter columns and smaller particles than those in conventional systems.

Original languageEnglish
Pages (from-to)2852-2871
Number of pages20
JournalAIChE Journal
Issue number11
Publication statusPublished - 2008 Nov
Externally publishedYes


  • Chiral separation
  • Genetic algorithm
  • Multiobjective optimization
  • Simulated moving oea chromatograpny
  • Standing wave design

ASJC Scopus subject areas

  • Biotechnology
  • Environmental Engineering
  • General Chemical Engineering


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