Simultaneous imaging of mitochondria and lysosomes by using two-photon fluorescent probes

Ji Hee Han, Sun Keun Park, Chang Su Lim, Min Kyu Park, Hyung Joong Kim, Hwan Myung Kim, Bong Rae Cho

    Research output: Contribution to journalArticlepeer-review

    44 Citations (Scopus)

    Abstract

    Dual-color imaging: Two-photon probes for lysosomes (BLT-blue) and mitochondria (FMT-green) that can be excited by 750 nm femtosecond laser pulses and emit at λ=400-450 and 550-600 nm, respectively, are reported. They allow simultaneous dual-color imaging of lysosomes and mitochondria in live cells and tissues for a long period of time with minimum interference from pH, photobleaching, or cytotoxicity (see scheme).

    Original languageEnglish
    Pages (from-to)15246-15249
    Number of pages4
    JournalChemistry - A European Journal
    Volume18
    Issue number48
    DOIs
    Publication statusPublished - 2012 Nov 26

    Keywords

    • fluorescence
    • fluorescent probes
    • imaging agents
    • lysosomes
    • mitochondria

    ASJC Scopus subject areas

    • Catalysis
    • General Chemistry
    • Organic Chemistry

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