Simultaneous measurement of 23 plasma cytokines in late-life depression

Kang Soo Lee, Ji Hyung Chung, Kyung Hye Lee, Min Jeong Shin, Byoung Hoon Oh, Soo Hyung Lee, Chang Hyung Hong

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


According to the cytokine hypothesis of depression, cytokines play key roles in the behavioral, neuroendocrinal, and neurochemical features of depression. In this study, we used a bioplex assay to simultaneously measure the levels of 23 plasma cytokines in 18 patients with late-life depression and 38 normal controls, and these levels were compared between the two groups. The plasma interleukin-1alpha (IL-1α) levels were found to be significantly different between the two groups. After adjusting for age, gender, low-density lipoprotein cholesterol, and triglyceride, the plasma IL-1α levels were significantly higher in the patients with late-life depression than in the normal control subjects. Thus, this study provides preliminary evidence that plasma IL-1α may play important roles in the pathogenesis of late-life depression.

Original languageEnglish
Pages (from-to)435-438
Number of pages4
JournalNeurological Sciences
Issue number5
Publication statusPublished - 2009
Externally publishedYes

Bibliographical note

Funding Information:
This study was supported by a grant (A050079) from the Korea Health 21 R&D Project of the Ministry of Health and Welfare, Republic of Korea.


  • Bioplex
  • Cytokine
  • Interleukin-1 alpha
  • Late-life depression
  • Plasma
  • Vascular risk factors

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health


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