According to the cytokine hypothesis of depression, cytokines play key roles in the behavioral, neuroendocrinal, and neurochemical features of depression. In this study, we used a bioplex assay to simultaneously measure the levels of 23 plasma cytokines in 18 patients with late-life depression and 38 normal controls, and these levels were compared between the two groups. The plasma interleukin-1alpha (IL-1α) levels were found to be significantly different between the two groups. After adjusting for age, gender, low-density lipoprotein cholesterol, and triglyceride, the plasma IL-1α levels were significantly higher in the patients with late-life depression than in the normal control subjects. Thus, this study provides preliminary evidence that plasma IL-1α may play important roles in the pathogenesis of late-life depression.
Bibliographical noteFunding Information:
This study was supported by a grant (A050079) from the Korea Health 21 R&D Project of the Ministry of Health and Welfare, Republic of Korea.
- Interleukin-1 alpha
- Late-life depression
- Vascular risk factors
ASJC Scopus subject areas
- Clinical Neurology
- Psychiatry and Mental health