Abstract
According to the cytokine hypothesis of depression, cytokines play key roles in the behavioral, neuroendocrinal, and neurochemical features of depression. In this study, we used a bioplex assay to simultaneously measure the levels of 23 plasma cytokines in 18 patients with late-life depression and 38 normal controls, and these levels were compared between the two groups. The plasma interleukin-1alpha (IL-1α) levels were found to be significantly different between the two groups. After adjusting for age, gender, low-density lipoprotein cholesterol, and triglyceride, the plasma IL-1α levels were significantly higher in the patients with late-life depression than in the normal control subjects. Thus, this study provides preliminary evidence that plasma IL-1α may play important roles in the pathogenesis of late-life depression.
Original language | English |
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Pages (from-to) | 435-438 |
Number of pages | 4 |
Journal | Neurological Sciences |
Volume | 30 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2009 |
Externally published | Yes |
Bibliographical note
Funding Information:This study was supported by a grant (A050079) from the Korea Health 21 R&D Project of the Ministry of Health and Welfare, Republic of Korea.
Keywords
- Bioplex
- Cytokine
- Interleukin-1 alpha
- Late-life depression
- Plasma
- Vascular risk factors
ASJC Scopus subject areas
- Dermatology
- Clinical Neurology
- Psychiatry and Mental health