Single and 14-day repeated oral toxicity studies of 70% ethanol extract of Lindera obtusiloba blume leaves

Chung Oui Hong, Young Seomun, Yun Chang Koo, Mi Hyun Nam, Hyun Ah Lee, Ji Hoon Kim, Wang-Zeng, Sung Yong Yang, Sung Hee Lee, Su Hwan No, Kwang Won Lee

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5 Citations (Scopus)


Lindera obtusiloba Blume (LO), which is widely distributed in Korea, Japan and China, has traditionally been used as a popular folk medicine for the treatment of fever, abdominal pain, bruise and extravation. The purpose of this study was to examine the toxicities of the single and 14-day repeated doses in Sprague-Dawley rats orally administrated with LO at doses of 0, 500, 1000, 2000 (14-day repeated toxicity test) and 5000 (single toxicity test) mg (dry weight)/kg of body weight/day. The results showed that there was no difference in body weight change, food intake, water consumption, or organ weight among different dose groups. Also we observed no death and abnormal clinical signs during the experimental period. Between the groups orally administered LO and the control group, there was no statistical significance in hematological test or serum biochemical values. There were no evidences of histopathological alteration as well as abnormal gross finding mediated by single and 14 days treatments with LO. These results suggest that no observed adverse effect level (NOAEL) of the oral application of LO was considered to be more than 2000 mg/kg in rats under the conditions employed in this study.

Original languageEnglish
Pages (from-to)1324-1330
Number of pages7
JournalJournal of the Korean Society of Food Science and Nutrition
Issue number10
Publication statusPublished - 2009 Oct


  • 14-day repeated dose toxicity
  • Lindera obtusiloba blume
  • Single dose toxicity

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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