Single-enzyme nanoparticles armored by a nanometer-scale organic/inorganic network

Jungbae Kim, Jay W. Grate

Research output: Contribution to journalArticlepeer-review

263 Citations (Scopus)


We have developed armored single-enzyme nanoparticles (SENs) that surround each enzyme molecule with a porous composite organic/inorganic network of less than a few nanometers thick. This approach has significantly stabilized two proteases (α-chymotrypsin, CT, and trypsin, TR), and the armor network around CT is sufficiently thin and porous that it does not place a large mass-transfer limitation on the substrate. These new hybrid enzyme nanostructures offer great potential as a method to stabilize enzymes for various applications.

Original languageEnglish
Pages (from-to)1219-1222
Number of pages4
JournalNano Letters
Issue number9
Publication statusPublished - 2003 Sept 1
Externally publishedYes

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering


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