Single-enzyme nanoparticles armored by a nanometer-scale organic/inorganic network

Jungbae Kim; Jay W. Grate

doi:10.1021/nl034404b

Single-enzyme nanoparticles armored by a nanometer-scale organic/inorganic network

Jungbae Kim^*
, Jay W. Grate

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

281 Citations (Scopus)

Abstract

We have developed armored single-enzyme nanoparticles (SENs) that surround each enzyme molecule with a porous composite organic/inorganic network of less than a few nanometers thick. This approach has significantly stabilized two proteases (α-chymotrypsin, CT, and trypsin, TR), and the armor network around CT is sufficiently thin and porous that it does not place a large mass-transfer limitation on the substrate. These new hybrid enzyme nanostructures offer great potential as a method to stabilize enzymes for various applications.

Original language	English
Pages (from-to)	1219-1222
Number of pages	4
Journal	Nano Letters
Volume	3
Issue number	9
DOIs	https://doi.org/10.1021/nl034404b
Publication status	Published - 2003 Sept 1
Externally published	Yes

ASJC Scopus subject areas

Bioengineering
General Chemistry
General Materials Science
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl034404b

Cite this

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abstract = "We have developed armored single-enzyme nanoparticles (SENs) that surround each enzyme molecule with a porous composite organic/inorganic network of less than a few nanometers thick. This approach has significantly stabilized two proteases (α-chymotrypsin, CT, and trypsin, TR), and the armor network around CT is sufficiently thin and porous that it does not place a large mass-transfer limitation on the substrate. These new hybrid enzyme nanostructures offer great potential as a method to stabilize enzymes for various applications.",

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AB - We have developed armored single-enzyme nanoparticles (SENs) that surround each enzyme molecule with a porous composite organic/inorganic network of less than a few nanometers thick. This approach has significantly stabilized two proteases (α-chymotrypsin, CT, and trypsin, TR), and the armor network around CT is sufficiently thin and porous that it does not place a large mass-transfer limitation on the substrate. These new hybrid enzyme nanostructures offer great potential as a method to stabilize enzymes for various applications.

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Single-enzyme nanoparticles armored by a nanometer-scale organic/inorganic network

Abstract

ASJC Scopus subject areas

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