Single gold nanoplasmonic sensor for clinical cancer diagnosis based on specific interaction between nucleic acids and protein

Xingyi Ma, Phuoc Long Truong, Nguyen Hung Anh, Sang Jun Sim

    Research output: Contribution to journalArticlepeer-review

    46 Citations (Scopus)

    Abstract

    Plasmonic nanomaterials reveal noble optical properties for next-generation biosensors. Nanoplasmonic biosensors have become simple, sensitive, smart, and consistent with advanced healthcare programs requirements. Notably, an individual nanoparticle analysis can yield unique target information, based on which the next-generation biosensor is revolutionary for end-point detection (single or multiplex), and can be functionally extended to biological phenomena monitoring. Here, we present a single nanoplasmonic sensing technology based on localized surface plasmon resonance for label-free and real-time detection of highly reliable cancer markers (mutant gene and telomerase) in clinical samples. The sensor specifically detects mutant DNA, and can detect telomerase from as few as 10 HeLa cells. This approach can be easily translated to detect other pathological targets with high sensitivity and specificity, and monitor key interactions between biomolecules such as nucleic acids and proteins during disease development in real time. This system has great potential to be further developed for on-chip and simultaneous analysis of multiple targets and interactions.

    Original languageEnglish
    Pages (from-to)59-65
    Number of pages7
    JournalBiosensors and Bioelectronics
    Volume67
    DOIs
    Publication statusPublished - 2015 May 5

    Bibliographical note

    Publisher Copyright:
    © 2014 Elsevier B.V.

    Keywords

    • Cancer cell
    • DNA mutation
    • Gold nanoparticle (AuNP)
    • Localized surface plasmon resonance (LSPR)
    • Nanoplasmonic sensor
    • Telomerase activity

    ASJC Scopus subject areas

    • Biotechnology
    • Biophysics
    • Biomedical Engineering
    • Electrochemistry

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