Single plasmonic nanostructures for biomedical diagnosis

Xingyi Ma, Sang Jun Sim

Research output: Contribution to journalReview articlepeer-review

10 Citations (Scopus)


The field of single nanoparticle plasmonics has grown enormously. There is no doubt that a wide diversity of the nanoplasmonic techniques and nanostructures represents a tremendous opportunity for fundamental biomedical studies as well as sensing and imaging applications. Single nanoparticle plasmonic biosensors are efficient in label-free single-molecule detection, as well as in monitoring real-time binding events of even several biomolecules. In the present review, we have discussed the prominent advantages and advances in single particle characterization and synthesis as well as new insight into and information on biomedical diagnosis uniquely obtained using single particle approaches. The approaches include the fundamental studies of nanoplasmonic behavior, two typical methods based on refractive index change and characteristic light intensity change, exciting innovations of synthetic strategies for new plasmonic nanostructures, and practical applications using single particle sensing, imaging, and tracking. The basic sphere and rod nanostructures are the focus of extensive investigations in biomedicine, while they can be programmed into algorithmic assemblies for novel plasmonic diagnosis. Design of single nanoparticles for the detection of single biomolecules will have far-reaching consequences in biomedical diagnosis.

Original languageEnglish
Pages (from-to)6197-6216
Number of pages20
JournalJournal of Materials Chemistry B
Issue number29
Publication statusPublished - 2020 Aug 7

Bibliographical note

Funding Information:
This study was supported by the National Research Foundation (NRF) grant (No. NRF-2019R1A2C3009821) of the National Research Foundation (NRF) of the Ministry of Science, ICT, and Future Planning of Korea.

Publisher Copyright:
© The Royal Society of Chemistry.

ASJC Scopus subject areas

  • General Chemistry
  • Biomedical Engineering
  • General Materials Science


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