Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli

William A. Rosche; Adam Jaworski; Seongman Kang; Shannon F. Kramer; Jacquelynn E. Larson; David P. Geidroc; Robert D. Wells; Richard R. Sinden

doi:10.1128/jb.178.16.5042-5044.1996

Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli

William A. Rosche, Adam Jaworski, Seongman Kang, Shannon F. Kramer, Jacquelynn E. Larson, David P. Geidroc, Robert D. Wells, Richard R. Sinden

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded- DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats.

Original language	English
Pages (from-to)	5042-5044
Number of pages	3
Journal	Journal of Bacteriology
Volume	178
Issue number	16
DOIs	https://doi.org/10.1128/jb.178.16.5042-5044.1996
Publication status	Published - 1996
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Molecular Biology

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10.1128/jb.178.16.5042-5044.1996

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title = "Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli",

abstract = "The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded- DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats.",

author = "Rosche, {William A.} and Adam Jaworski and Seongman Kang and Kramer, {Shannon F.} and Larson, {Jacquelynn E.} and Geidroc, {David P.} and Wells, {Robert D.} and Sinden, {Richard R.}",

year = "1996",

doi = "10.1128/jb.178.16.5042-5044.1996",

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T1 - Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli

AU - Rosche, William A.

AU - Jaworski, Adam

AU - Kang, Seongman

AU - Kramer, Shannon F.

AU - Larson, Jacquelynn E.

AU - Geidroc, David P.

AU - Wells, Robert D.

AU - Sinden, Richard R.

PY - 1996

Y1 - 1996

N2 - The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded- DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats.

AB - The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded- DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats.

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U2 - 10.1128/jb.178.16.5042-5044.1996

DO - 10.1128/jb.178.16.5042-5044.1996

M3 - Article

C2 - 8759875

AN - SCOPUS:0029762671

SN - 0021-9193

VL - 178

SP - 5042

EP - 5044

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 16

ER -

Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli

Abstract

ASJC Scopus subject areas

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