Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli

William A. Rosche; Adam Jaworski; Seongman Kang; Shannon F. Kramer; Jacquelynn E. Larson; David P. Geidroc; Robert D. Wells; Richard R. Sinden

doi:10.1128/jb.178.16.5042-5044.1996

Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli

William A. Rosche
, Adam Jaworski
, Seongman Kang
, Shannon F. Kramer
, Jacquelynn E. Larson
, David P. Geidroc
, Robert D. Wells
, Richard R. Sinden^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded- DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats.

Original language	English
Pages (from-to)	5042-5044
Number of pages	3
Journal	Journal of Bacteriology
Volume	178
Issue number	16
DOIs	https://doi.org/10.1128/jb.178.16.5042-5044.1996
Publication status	Published - 1996
Externally published	Yes

ASJC Scopus subject areas

Microbiology
Molecular Biology

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10.1128/jb.178.16.5042-5044.1996

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title = "Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli",

abstract = "The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded- DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats.",

author = "Rosche, \{William A.\} and Adam Jaworski and Seongman Kang and Kramer, \{Shannon F.\} and Larson, \{Jacquelynn E.\} and Geidroc, \{David P.\} and Wells, \{Robert D.\} and Sinden, \{Richard R.\}",

year = "1996",

doi = "10.1128/jb.178.16.5042-5044.1996",

language = "English",

volume = "178",

pages = "5042--5044",

journal = "Journal of Bacteriology",

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publisher = "American Society for Microbiology",

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T1 - Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli

AU - Rosche, William A.

AU - Jaworski, Adam

AU - Kang, Seongman

AU - Kramer, Shannon F.

AU - Larson, Jacquelynn E.

AU - Geidroc, David P.

AU - Wells, Robert D.

AU - Sinden, Richard R.

PY - 1996

Y1 - 1996

N2 - The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded- DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats.

AB - The stability of CTG triplet repeats was analyzed in Escherichia coli to identify processes responsible for their genetic instability. Using a biochemical assay for stability, we show that the absence of single-stranded- DNA-binding protein leads to an increase in the frequency of large deletions within the triplet repeats.

UR - https://www.scopus.com/pages/publications/0029762671

U2 - 10.1128/jb.178.16.5042-5044.1996

DO - 10.1128/jb.178.16.5042-5044.1996

M3 - Article

C2 - 8759875

AN - SCOPUS:0029762671

SN - 0021-9193

VL - 178

SP - 5042

EP - 5044

JO - Journal of Bacteriology

JF - Journal of Bacteriology

IS - 16

ER -

Single-stranded DNA-binding protein enhances the stability of CTG triplet repeats in Escherichia coli

Abstract

ASJC Scopus subject areas

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