Site-Invariant Meta-Modulation Learning for Multisite Autism Spectrum Disorders Diagnosis

Jaein Lee, Eunsong Kang, Da Woon Heo, Heung Il Suk

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)

    Abstract

    Large amounts of fMRI data are essential to building generalized predictive models for brain disease diagnosis. In order to conduct extensive data analysis, it is often necessary to gather data from multiple organizations. However, the site variation inherent in multisite resting-state functional magnetic resonance imaging (rs-fMRI) leads to unfavorable heterogeneity in data distribution, negatively impacting the identification of biomarkers and the diagnostic decision. Several existing methods have alleviated this shift of domain distribution (i.e., multisite problem). Statistical tuning schemes directly regress out site disparity factors from the data prior to model training. Such methods have a limitation in processing data each time through variance estimation according to the added site. In the model adjustment approaches, domain adaptation (DA) methods adjust the features or models of the source domain according to the target domain during model training. Thus, it is inevitable that it needs updating model parameters according to the samples of a target site, causing great limitations in practical applicability. Meanwhile, the approach of domain generalization (DG) aims to create a universal model that can be quickly adapted to multiple domains. In this study, we propose a novel framework for disease diagnosis that alleviates the multisite problem by adaptively calibrating site-specific features into site-invariant features. Specifically, it applies directly to samples from unseen sites without the need for fine-tuning. With a learning-to-learn strategy that learns how to calibrate the features under the various domain shift environments, our novel modulation mechanism extracts site-invariant features. In our experiments over the Autism Brain Imaging Data Exchange (ABIDE I and II) dataset, we validated the generalization ability of the proposed network by improving diagnostic accuracy in both seen and unseen multisite samples.

    Original languageEnglish
    Pages (from-to)1-14
    Number of pages14
    JournalIEEE Transactions on Neural Networks and Learning Systems
    DOIs
    Publication statusAccepted/In press - 2023

    Bibliographical note

    Publisher Copyright:
    IEEE

    Keywords

    • Adaptation models
    • Autism spectrum disorder (ASD)
    • Brain modeling
    • Data models
    • domain generalization (DG)
    • Feature extraction
    • Functional magnetic resonance imaging
    • meta-learning
    • Metalearning
    • modulation network
    • multisite fMRI
    • Task analysis

    ASJC Scopus subject areas

    • Software
    • Computer Science Applications
    • Computer Networks and Communications
    • Artificial Intelligence

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