SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy

Yoon Kyung Park; Paramesh Jangili; Soyu Zi; Rae Hyung Kang; Dokyoung Kim; Jong Seung Kim

doi:10.1039/d2cc03777g

SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy

Yoon Kyung Park, Paramesh Jangili, Soyu Zi, Rae Hyung Kang, Dokyoung Kim, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

A new conjugate formulation, SIWV-PB-SN, based on glioblastoma (GBM)-homing SIWV tetrapeptide and an ROS-responsive prodrug is reported. SIWV-PB-SN selectively penetrates the GBM cells and releases anti-GBM drug (SN-38) via ROS-induced linker cleavage. This study presents a new insight for a more advanced therapeutic approach to overcoming GBM.

Original language	English
Pages (from-to)	10941-10944
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	78
DOIs	https://doi.org/10.1039/d2cc03777g
Publication status	Published - 2022 Sept 9

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy",

abstract = "A new conjugate formulation, SIWV-PB-SN, based on glioblastoma (GBM)-homing SIWV tetrapeptide and an ROS-responsive prodrug is reported. SIWV-PB-SN selectively penetrates the GBM cells and releases anti-GBM drug (SN-38) via ROS-induced linker cleavage. This study presents a new insight for a more advanced therapeutic approach to overcoming GBM.",

author = "Park, {Yoon Kyung} and Paramesh Jangili and Soyu Zi and Kang, {Rae Hyung} and Dokyoung Kim and Kim, {Jong Seung}",

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AU - Park, Yoon Kyung

AU - Jangili, Paramesh

AU - Zi, Soyu

AU - Kang, Rae Hyung

AU - Kim, Dokyoung

AU - Kim, Jong Seung

PY - 2022/9/9

Y1 - 2022/9/9

N2 - A new conjugate formulation, SIWV-PB-SN, based on glioblastoma (GBM)-homing SIWV tetrapeptide and an ROS-responsive prodrug is reported. SIWV-PB-SN selectively penetrates the GBM cells and releases anti-GBM drug (SN-38) via ROS-induced linker cleavage. This study presents a new insight for a more advanced therapeutic approach to overcoming GBM.

AB - A new conjugate formulation, SIWV-PB-SN, based on glioblastoma (GBM)-homing SIWV tetrapeptide and an ROS-responsive prodrug is reported. SIWV-PB-SN selectively penetrates the GBM cells and releases anti-GBM drug (SN-38) via ROS-induced linker cleavage. This study presents a new insight for a more advanced therapeutic approach to overcoming GBM.

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U2 - 10.1039/d2cc03777g

DO - 10.1039/d2cc03777g

M3 - Article

C2 - 36082694

AN - SCOPUS:85139240733

SN - 1359-7345

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SP - 10941

EP - 10944

JO - Chemical Communications

JF - Chemical Communications

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ER -

SIWV tetrapeptide and ROS-responsive prodrug conjugate for advanced glioblastoma therapy

Abstract

ASJC Scopus subject areas

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