Skin discolouration with acute onset parkinsonism secondary to systemic zirconium intoxication

Hwa J. Ryu, Su J. Yoon, Jong Tae Park, Young H. Kim, Jin M. Jung, Moon Ho Park, Im J. Rhyu, Do Young Kwon

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


A 72-year-old woman presented with suspected parkinsonism and discolouration of the skin especially on sun-exposed areas. Thorough investigation revealed systemic zirconium intoxication due to intake of metallic colloids as a home remedy as a cause of the skin colour change. There may be an association between skin discolouration and her parkinsonism. This is unique in that various clinical manifestations developed following systemic ingestion of zirconium and this should serve as a warning on the risk of taking illicit dietary supplements.

Original languageEnglish
Pages (from-to)97-100
Number of pages4
JournalAnnals of Clinical Biochemistry
Issue number1
Publication statusPublished - 2014 Jan 1

Bibliographical note

Funding Information:
This study was supported by a Korea University Grant in performing Laboratory study.


  • Clinical studies
  • Intoxication
  • Parkinsonism
  • Skin discolouration
  • Toxicology
  • Zirconium

ASJC Scopus subject areas

  • Clinical Biochemistry


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