Skin-interfaced electronics: A promising and intelligent paradigm for personalized healthcare

Yangzhi Zhu, Jinghang Li, Jinjoo Kim, Shaopei Li, Yichao Zhao, Jamal Bahari, Payam Eliahoo, Guanghui Li, Satoru Kawakita, Reihaneh Haghniaz, Xiaoxiang Gao, Natashya Falcone, Menekse Ermis, Heemin Kang, Hao Liu, Han Jun Kim, Tanveer Tabish, Haidong Yu, Bingbing Li, Mohsen AkbariSam Emaminejad, Ali Khademhosseini

Research output: Contribution to journalReview articlepeer-review

2 Citations (Scopus)


Skin-interfaced electronics (skintronics) have received considerable attention due to their thinness, skin-like mechanical softness, excellent conformability, and multifunctional integration. Current advancements in skintronics have enabled health monitoring and digital medicine. Particularly, skintronics offer a personalized platform for early-stage disease diagnosis and treatment. In this comprehensive review, we discuss (1) the state-of-the-art skintronic devices, (2) material selections and platform considerations of future skintronics toward intelligent healthcare, (3) device fabrication and system integrations of skintronics, (4) an overview of the skintronic platform for personalized healthcare applications, including biosensing as well as wound healing, sleep monitoring, the assessment of SARS-CoV-2, and the augmented reality-/virtual reality-enhanced human-machine interfaces, and (5) current challenges and future opportunities of skintronics and their potentials in clinical translation and commercialization. The field of skintronics will not only minimize physical and physiological mismatches with the skin but also shift the paradigm in intelligent and personalized healthcare and offer unprecedented promise to revolutionize conventional medical practices.

Original languageEnglish
Article number122075
Publication statusPublished - 2023 May

Bibliographical note

Funding Information:
The authors acknowledge the start-up funding from the Terasaki Institute for Biomedical Innovation and the funding from the National Institute of Health ( DK128711-01 ).

Publisher Copyright:
© 2023 Elsevier Ltd


  • Biomaterials
  • Biosensors
  • Flexible bioelectronics
  • Machine learning
  • Personalized healthcare
  • Strain-insensitive

ASJC Scopus subject areas

  • Mechanics of Materials
  • Ceramics and Composites
  • Bioengineering
  • Biophysics
  • Biomaterials


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