Slow dendritic transport of dissociated mouse hippocampal neurons exposed to aluminum

Ikuro Wakayama; Ki Joon Song; Vivek R. Nerurkar; Sohei Yoshida; Ralph M. Garruto

doi:10.1016/S0006-8993(96)01314-5

Slow dendritic transport of dissociated mouse hippocampal neurons exposed to aluminum

Ikuro Wakayama, Ki Joon Song, Vivek R. Nerurkar, Sohei Yoshida, Ralph M. Garruto

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

We determined the influence of aluminum on dendritic transport, using an in vitro system of dissociated mouse hippocampal neurons. Newly synthesized RNA from dissociated mouse hippocampal neurons was more slowly transported into dendrites in the presence of aluminum chloride when compared to those without the addition of aluminum chloride to the culture medium. Suppression of dendritic transport of newly synthesized RNA may be responsible for the dendritic degeneration observed in aluminum neurotoxicity, eventually leading to neuronal degeneration.

Original language	English
Pages (from-to)	237-240
Number of pages	4
Journal	Brain Research
Volume	748
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(96)01314-5
Publication status	Published - 1997 Feb 14

Keywords

Alzheimer's disease
Guam
RNA
amyotrophic lateral sclerosis
axonal transport
cell culture
neurotoxin
parkinsonism-dementia

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(96)01314-5

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title = "Slow dendritic transport of dissociated mouse hippocampal neurons exposed to aluminum",

abstract = "We determined the influence of aluminum on dendritic transport, using an in vitro system of dissociated mouse hippocampal neurons. Newly synthesized RNA from dissociated mouse hippocampal neurons was more slowly transported into dendrites in the presence of aluminum chloride when compared to those without the addition of aluminum chloride to the culture medium. Suppression of dendritic transport of newly synthesized RNA may be responsible for the dendritic degeneration observed in aluminum neurotoxicity, eventually leading to neuronal degeneration.",

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AU - Wakayama, Ikuro

AU - Song, Ki Joon

AU - Nerurkar, Vivek R.

AU - Yoshida, Sohei

AU - Garruto, Ralph M.

PY - 1997/2/14

Y1 - 1997/2/14

N2 - We determined the influence of aluminum on dendritic transport, using an in vitro system of dissociated mouse hippocampal neurons. Newly synthesized RNA from dissociated mouse hippocampal neurons was more slowly transported into dendrites in the presence of aluminum chloride when compared to those without the addition of aluminum chloride to the culture medium. Suppression of dendritic transport of newly synthesized RNA may be responsible for the dendritic degeneration observed in aluminum neurotoxicity, eventually leading to neuronal degeneration.

AB - We determined the influence of aluminum on dendritic transport, using an in vitro system of dissociated mouse hippocampal neurons. Newly synthesized RNA from dissociated mouse hippocampal neurons was more slowly transported into dendrites in the presence of aluminum chloride when compared to those without the addition of aluminum chloride to the culture medium. Suppression of dendritic transport of newly synthesized RNA may be responsible for the dendritic degeneration observed in aluminum neurotoxicity, eventually leading to neuronal degeneration.

KW - Alzheimer's disease

KW - Guam

KW - RNA

KW - amyotrophic lateral sclerosis

KW - axonal transport

KW - cell culture

KW - neurotoxin

KW - parkinsonism-dementia

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JF - Brain Research

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ER -

Slow dendritic transport of dissociated mouse hippocampal neurons exposed to aluminum

Abstract

Keywords

ASJC Scopus subject areas

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