Abstract
Background: Cooperation between transcription factors and myogenic regulatory factors is important for skeletal muscle differentiation. Results: sLZIP inhibits expression of muscle-specific genes during myogenesis via disruption of an association betweenα-actinin- 4 and MEF2. Conclusion: A novel myogenesis regulatory mechanism of sLZIP is characterized. Significance: sLZIP can be used as a therapeutic target for treatment of muscle diseases.
Original language | English |
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Pages (from-to) | 4969-4979 |
Number of pages | 11 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2014 Feb 21 |
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology