Small leucine zipper protein (sLZIP) negatively regulates skeletal muscle differentiation via interaction with α-actinin-4

Hyoung Tae An, Jeonghan Kim, Seungmin Yoo, Jesang Ko

    Research output: Contribution to journalArticlepeer-review

    14 Citations (Scopus)

    Abstract

    Background: Cooperation between transcription factors and myogenic regulatory factors is important for skeletal muscle differentiation. Results: sLZIP inhibits expression of muscle-specific genes during myogenesis via disruption of an association betweenα-actinin- 4 and MEF2. Conclusion: A novel myogenesis regulatory mechanism of sLZIP is characterized. Significance: sLZIP can be used as a therapeutic target for treatment of muscle diseases.

    Original languageEnglish
    Pages (from-to)4969-4979
    Number of pages11
    JournalJournal of Biological Chemistry
    Volume289
    Issue number8
    DOIs
    Publication statusPublished - 2014 Feb 21

    ASJC Scopus subject areas

    • Biochemistry
    • Molecular Biology
    • Cell Biology

    Fingerprint

    Dive into the research topics of 'Small leucine zipper protein (sLZIP) negatively regulates skeletal muscle differentiation via interaction with α-actinin-4'. Together they form a unique fingerprint.

    Cite this