Smart Acid-Activatable Self-Assembly of Black Phosphorous as Photosensitizer to Overcome Poor Tumor Retention in Photothermal Therapy

Yingwei Wang; Jianlei Xie; Jianlong Kang; Wonseok Choi; Paramesh Jangili; Bin Zhang; Ni Xie; Guohui Nie; Jun He; Han Zhang; Liping Liu; Jong Seung Kim

doi:10.1002/adfm.202003338

Smart Acid-Activatable Self-Assembly of Black Phosphorous as Photosensitizer to Overcome Poor Tumor Retention in Photothermal Therapy

Yingwei Wang, Jianlei Xie, Jianlong Kang, Wonseok Choi, Paramesh Jangili, Bin Zhang, Ni Xie, Guohui Nie, Jun He, Han Zhang, Liping Liu, Jong Seung Kim

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

Nanomaterials-based photothermal therapy (PTT) could efficiently eliminate cancer cells in a noninvasive manner. However, nanoscale photosensitizers still suffer from several drawbacks, limiting them from being an ideal PTT approach against cancer. These include unfavorable biodistribution and poor retention in tumor tissue. In this study, acid-activatable smart self-assembly of black phosphorous (BP) and polyoxometalates (POM) is carried out to yield POM@BP with prolonged tumor retention and enhanced efficacy of PTT. The as-rationally designed POM@BP photosensitizers in acidic tumor microenvironments self-assemble into nanoparticles with larger sizes, remarkably increasing the light absorption ability of BP nanosheets in PTT of cancer. The as-obtained POM@BP endows prolonged retention and enhances the photothermal response in tumor tissue by smart self-assembly of BP into larger nanoparticles. In summary, the proposed potent approach for the rational design and tailor photosensitizer for cancer treatment looks very promising for future scientific breakthroughs in nanomedicine.

Original language	English
Article number	2003338
Journal	Advanced Functional Materials
Volume	30
Issue number	42
DOIs	https://doi.org/10.1002/adfm.202003338
Publication status	Published - 2020 Oct 1

Bibliographical note

Funding Information:
Y.W., J.X., and J.K. contributed equally to this work. This research was partially supported by the National Natural Science Foundation of China (Grant No. 61874141; 11904239), the Science and Technology Innovation Commission of Shenzhen (Grant No. JCYJ20170818141407343), and CRI project (No. 2018R1A3B1052702, JSK) of the National Research Foundation of Korea.

Funding Information:
Y.W., J.X., and J.K. contributed equally to this work. This research was partially supported by the National Natural Science Foundation of China (Grant No. 61874141; 11904239), the Science and Technology Innovation Commission of Shenzhen (Grant No. JCYJ20170818141407343), and CRI project (No. 2018R1A3B1052702, JSK) of the National Research Foundation of Korea.

Publisher Copyright:
© 2020 Wiley-VCH GmbH

Keywords

2D materials
acid activatable
cancer therapy
photothermal therapy
polyoxometalate

ASJC Scopus subject areas

General Chemistry
General Materials Science
Condensed Matter Physics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/adfm.202003338

Cite this

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title = "Smart Acid-Activatable Self-Assembly of Black Phosphorous as Photosensitizer to Overcome Poor Tumor Retention in Photothermal Therapy",

abstract = "Nanomaterials-based photothermal therapy (PTT) could efficiently eliminate cancer cells in a noninvasive manner. However, nanoscale photosensitizers still suffer from several drawbacks, limiting them from being an ideal PTT approach against cancer. These include unfavorable biodistribution and poor retention in tumor tissue. In this study, acid-activatable smart self-assembly of black phosphorous (BP) and polyoxometalates (POM) is carried out to yield POM@BP with prolonged tumor retention and enhanced efficacy of PTT. The as-rationally designed POM@BP photosensitizers in acidic tumor microenvironments self-assemble into nanoparticles with larger sizes, remarkably increasing the light absorption ability of BP nanosheets in PTT of cancer. The as-obtained POM@BP endows prolonged retention and enhances the photothermal response in tumor tissue by smart self-assembly of BP into larger nanoparticles. In summary, the proposed potent approach for the rational design and tailor photosensitizer for cancer treatment looks very promising for future scientific breakthroughs in nanomedicine.",

keywords = "2D materials, acid activatable, cancer therapy, photothermal therapy, polyoxometalate",

author = "Yingwei Wang and Jianlei Xie and Jianlong Kang and Wonseok Choi and Paramesh Jangili and Bin Zhang and Ni Xie and Guohui Nie and Jun He and Han Zhang and Liping Liu and Kim, {Jong Seung}",

note = "Funding Information: Y.W., J.X., and J.K. contributed equally to this work. This research was partially supported by the National Natural Science Foundation of China (Grant No. 61874141; 11904239), the Science and Technology Innovation Commission of Shenzhen (Grant No. JCYJ20170818141407343), and CRI project (No. 2018R1A3B1052702, JSK) of the National Research Foundation of Korea. Funding Information: Y.W., J.X., and J.K. contributed equally to this work. This research was partially supported by the National Natural Science Foundation of China (Grant No. 61874141; 11904239), the Science and Technology Innovation Commission of Shenzhen (Grant No. JCYJ20170818141407343), and CRI project (No. 2018R1A3B1052702, JSK) of the National Research Foundation of Korea. Publisher Copyright: {\textcopyright} 2020 Wiley-VCH GmbH",

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doi = "10.1002/adfm.202003338",

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AU - Wang, Yingwei

AU - Xie, Jianlei

AU - Kang, Jianlong

AU - Choi, Wonseok

AU - Jangili, Paramesh

AU - Zhang, Bin

AU - Xie, Ni

AU - Nie, Guohui

AU - He, Jun

AU - Zhang, Han

AU - Liu, Liping

AU - Kim, Jong Seung

N1 - Funding Information: Y.W., J.X., and J.K. contributed equally to this work. This research was partially supported by the National Natural Science Foundation of China (Grant No. 61874141; 11904239), the Science and Technology Innovation Commission of Shenzhen (Grant No. JCYJ20170818141407343), and CRI project (No. 2018R1A3B1052702, JSK) of the National Research Foundation of Korea. Funding Information: Y.W., J.X., and J.K. contributed equally to this work. This research was partially supported by the National Natural Science Foundation of China (Grant No. 61874141; 11904239), the Science and Technology Innovation Commission of Shenzhen (Grant No. JCYJ20170818141407343), and CRI project (No. 2018R1A3B1052702, JSK) of the National Research Foundation of Korea. Publisher Copyright: © 2020 Wiley-VCH GmbH

PY - 2020/10/1

Y1 - 2020/10/1

N2 - Nanomaterials-based photothermal therapy (PTT) could efficiently eliminate cancer cells in a noninvasive manner. However, nanoscale photosensitizers still suffer from several drawbacks, limiting them from being an ideal PTT approach against cancer. These include unfavorable biodistribution and poor retention in tumor tissue. In this study, acid-activatable smart self-assembly of black phosphorous (BP) and polyoxometalates (POM) is carried out to yield POM@BP with prolonged tumor retention and enhanced efficacy of PTT. The as-rationally designed POM@BP photosensitizers in acidic tumor microenvironments self-assemble into nanoparticles with larger sizes, remarkably increasing the light absorption ability of BP nanosheets in PTT of cancer. The as-obtained POM@BP endows prolonged retention and enhances the photothermal response in tumor tissue by smart self-assembly of BP into larger nanoparticles. In summary, the proposed potent approach for the rational design and tailor photosensitizer for cancer treatment looks very promising for future scientific breakthroughs in nanomedicine.

AB - Nanomaterials-based photothermal therapy (PTT) could efficiently eliminate cancer cells in a noninvasive manner. However, nanoscale photosensitizers still suffer from several drawbacks, limiting them from being an ideal PTT approach against cancer. These include unfavorable biodistribution and poor retention in tumor tissue. In this study, acid-activatable smart self-assembly of black phosphorous (BP) and polyoxometalates (POM) is carried out to yield POM@BP with prolonged tumor retention and enhanced efficacy of PTT. The as-rationally designed POM@BP photosensitizers in acidic tumor microenvironments self-assemble into nanoparticles with larger sizes, remarkably increasing the light absorption ability of BP nanosheets in PTT of cancer. The as-obtained POM@BP endows prolonged retention and enhances the photothermal response in tumor tissue by smart self-assembly of BP into larger nanoparticles. In summary, the proposed potent approach for the rational design and tailor photosensitizer for cancer treatment looks very promising for future scientific breakthroughs in nanomedicine.

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KW - polyoxometalate

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U2 - 10.1002/adfm.202003338

DO - 10.1002/adfm.202003338

M3 - Article

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SN - 1616-301X

VL - 30

JO - Advanced Functional Materials

JF - Advanced Functional Materials

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M1 - 2003338

ER -

Smart Acid-Activatable Self-Assembly of Black Phosphorous as Photosensitizer to Overcome Poor Tumor Retention in Photothermal Therapy

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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