Sodium-ion-selective two-photon fluorescent probe for in vivo imaging

Mi Kyung Kim, Chang Su Lim, Jong Tae Hong, Ji Hee Han, Hye Young Jang, Hwan Myung Kim, Bong Rae Cho

Research output: Contribution to journalArticlepeer-review

101 Citations (Scopus)


"Chemical Equation Presented" Two photons are better than one: A two-photon probe (ANa1, see picture) shows strong twophoton fluorescence enhancement In response to Na+ and a dissociation constant (K dl) of (26±2) mM in the cell. It can be easily loaded into the cells and can selectively detect intracellular free Na + in live cells and living tissues at a depth of 100-200 μm for a long period of time.

Original languageEnglish
Pages (from-to)364-367
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number2
Publication statusPublished - 2010 Jan 8


  • Fluorescent probes
  • Live tissue
  • Sodium
  • Two-photon microscopy

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry


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