Soil biota, antimicrobial resistance and planetary health

Yong Guan Zhu, Yi Zhao, Dong Zhu, Michael Gillings, J. Penuelas, Yong Sik Ok, Anthony Capon, S. Banwart

Research output: Contribution to journalReview articlepeer-review

165 Citations (Scopus)

Abstract

The concept of planetary health acknowledges the links between ecosystems, biodiversity and human health and well-being. Soil, the critical component of the interconnected ecosystem, is the most biodiverse habitat on Earth, and soil microbiomes play a major role in human health and well-being through ecosystem services such as nutrient cycling, pollutant remediation and synthesis of bioactive compounds such as antimicrobials. Soil is also a natural source of antimicrobial resistance, which is often termed intrinsic resistance. However, increasing use and misuse of antimicrobials in humans and animals in recent decades has increased both the diversity and prevalence of antimicrobial resistance in soils, particularly in areas affected by human and animal wastes, such as organic manures and reclaimed wastewater, and also by air transmission. Antimicrobials and antimicrobial resistance are two sides of the sword, while antimicrobials are essential in health care; globally, antimicrobial resistance is jeopardizing the effectiveness of antimicrobial drugs, thus threatening human health. Soil is a crucial pathway through which humans are exposed to antimicrobial resistance determinants, including those harbored by human pathogens. In this review, we use the nexus of antimicrobials and antimicrobial resistance as a focus to discuss the role of soil in planetary health and illustrate the impacts of soil microbiomes on human health and well-being. This review examines the sources and dynamics of antimicrobial resistance in soils and uses the perspective of planetary health to track the movement of antimicrobial-resistance genes between environmental compartments, including soil, water, food and air.

Original languageEnglish
Article number105059
JournalEnvironment international
Volume131
DOIs
Publication statusPublished - 2019 Oct

Bibliographical note

Funding Information:
We thank many people for helping collect samples. This work was funded by the National Natural Science Foundation of China (41571130063), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB15020302 and XDB15020402) and the National Key Research and Development Program of China-International collaborative project from Ministry of Science and Technology (Grant No. 2017YFE0107300). Authors want to specially thank MS Hui-Ling Cui for helping in developing the graphs. Y.G.Z. conceived the manuscript. Y.G.Z. Y.Z. and D.Z. wrote the manuscript. M. G. J. P. Y.S.O. A.C. and S.B. edited the manuscript.

Funding Information:
We thank many people for helping collect samples. This work was funded by the National Natural Science Foundation of China ( 41571130063 ), the Strategic Priority Research Program of the Chinese Academy of Sciences ( XDB15020302 and XDB15020402 ) and the National Key Research and Development Program of China-International collaborative project from Ministry of Science and Technolog y (Grant No. 2017YFE0107300 ). Authors want to specially thank MS Hui-Ling Cui for helping in developing the graphs.

Publisher Copyright:
© 2019 The Authors

Keywords

  • Antimicrobials
  • Human health
  • Planetary health
  • Resistome
  • Soil microbiome

ASJC Scopus subject areas

  • General Environmental Science

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