Solid lipid nanoparticles loaded thermoresponsive pluronic–xanthan gum hydrogel as a transdermal delivery system

Min Hyeock Lee, Gye Hwa Shin, Hyun Jin Park

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


The aim of this study was to develop and investigate thermoresponsive hydrogel incorporating curcumin (Cur) for application as a transdermal delivery system. Cur was encapsulated within solid lipid nanoparticles via ultrasonic homogenization, and these were introduced into a thermoresponsive hydrogel composed of pluronic F68 (PF68) and F127 (PF127). The hydrogel composed of PF68 and PF127 in 10:90 ratio transformed from sol to gel at 29.3 °C close to skin temperature. The skin adhesiveness and adhesive strength of the hydrogel with 0.2% (w/w) of XG was 1.64 and 1.24 times higher than those of the hydrogel without XG, respectively. The physiochemical characteristics of prepared formulations were investigated via observation of particle size, polydispersity index, transmission electron microscopy, and scanning electron microscopy. Moreover, Fourier transform infrared spectroscopy analysis was performed at physiological temperature, which revealed lower hydrogen bonding intensity at gel phase than at sol phase. The cumulative amount of Cur that penetrated significantly increased compared with the Cur ethanol solution.

Original languageEnglish
Article number46004
JournalJournal of Applied Polymer Science
Issue number11
Publication statusPublished - 2018 Mar 15

Bibliographical note

Funding Information:
This research was supported by a grant from School of Life Sciences and Biotechnology for BK21PLUS, Korea University and by Institute of Biomedical Science & Food Safety, Korea University. This research was also supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (contract grant number NRF-2017R1A2B4002240).

Publisher Copyright:
© 2017 Wiley Periodicals, Inc.


  • drug delivery systems
  • gels
  • nanoparticles
  • nanowires and nanocrystals
  • rheology
  • stimuli-sensitive polymers

ASJC Scopus subject areas

  • General Chemistry
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry


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